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Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation

Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of b...

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Hauptverfasser: Freedman, Andrew N. (VerfasserIn) , Sansbury, Leah B. (VerfasserIn) , Figg, William D. (VerfasserIn) , Potosky, Arnold L. (VerfasserIn) , Weiss Smith, Sheila R. (VerfasserIn) , Khoury, Muin J. (VerfasserIn) , Nelson, Stefanie A. (VerfasserIn) , Weinshilboum, Richard M. (VerfasserIn) , Ratain, Mark J. (VerfasserIn) , McLeod, Howard L. (VerfasserIn) , Epstein, Robert S. (VerfasserIn) , Ginsburg, Geoffrey S. (VerfasserIn) , Schilsky, Richard L. (VerfasserIn) , Liu, Geoffrey (VerfasserIn) , Flockhart, David A. (VerfasserIn) , Ulrich, Cornelia (VerfasserIn) , Davis, Robert L. (VerfasserIn) , Lesko, Lawrence J. (VerfasserIn) , Zineh, Issam (VerfasserIn) , Randhawa, Gurvaneet (VerfasserIn) , Ambrosone, Christine (VerfasserIn) , Relling, Mary V. (VerfasserIn) , Rothman, Ella Natalie (VerfasserIn) , Xie, Heng (VerfasserIn) , Spitz, Margaret R. (VerfasserIn) , Ballard-Barbash, Rachel (VerfasserIn) , Doroshow, James H. (VerfasserIn) , Minasian, Lori M. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 13 October 2010
In: Journal of the National Cancer Institute
Year: 2010, Jahrgang: 102, Heft: 22, Pages: 1698-1705
ISSN:1460-2105
DOI:10.1093/jnci/djq390
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/jnci/djq390
Volltext
Verfasserangaben:Andrew N. Freedman, Leah B. Sansbury, William D. Figg, Arnold L. Potosky, Sheila R. Weiss Smith, Muin J. Khoury, Stefanie A. Nelson, Richard M. Weinshilboum, Mark J. Ratain, Howard L. McLeod, Robert S. Epstein, Geoffrey S. Ginsburg, Richard L. Schilsky, Geoffrey Liu, David A. Flockhart, Cornelia M. Ulrich, Robert L. Davis, Lawrence J. Lesko, Issam Zineh, Gurvaneet Randhawa, Christine B. Ambrosone, Mary V. Relling, Nat Rothman, Heng Xie, Margaret R. Spitz, Rachel Ballard-Barbash, James H. Doroshow, Lori M. Minasian
Beschreibung
Zusammenfassung:Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of both adverse effects and treatment efficacy. To identify research priorities as well as the resources and infrastructure needed to advance these fields, the National Cancer Institute (NCI) sponsored a workshop titled “Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation” on July 21, 2009, in Bethesda, MD. In this commentary, we summarize and discuss five science-based recommendations and four infrastructure-based recommendations that were identified as a result of discussions held during this workshop. Key recommendations include 1) supporting the routine collection of germline and tumor biospecimens in NCI-sponsored clinical trials and in some observational and population-based studies; 2) incorporating pharmacogenomic markers into clinical trials; 3) addressing the ethical, legal, social, and biospecimen- and data-sharing implications of pharmacogenomic and pharmacoepidemiologic research; and 4) establishing partnerships across NCI, with other federal agencies, and with industry. Together, these recommendations will facilitate the discovery and validation of clinical, sociodemographic, lifestyle, and genomic markers related to cancer treatment response and adverse events, and they will improve both the speed and efficiency by which new pharmacogenomic and pharmacoepidemiologic information is translated into clinical practice.
Beschreibung:Gesehen am 19.12.2023
Beschreibung:Online Resource
ISSN:1460-2105
DOI:10.1093/jnci/djq390

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