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Enablers and challenges of spatial omics, a melting pot of technologies

Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of publications presenting novel methods for obtaining spatially resolved information for any omics data type on spatial scales ranging from subcellular to organismal. From a technology development perspective, spatial o...

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Bibliographic Details
Main Authors: Alexandrov, Theodore (Author) , Sáez Rodríguez, Julio (Author) , Saka, Sinem (Author)
Format: Article (Journal)
Language:English
Published: Nov 2023
In: Molecular systems biology
Year: 2023, Volume: 19, Issue: 11, Pages: 1-16
ISSN:1744-4292
DOI:10.15252/msb.202110571
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.15252/msb.202110571
Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.15252/msb.202110571
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Author Notes:Theodore Alexandrov, Julio Saez‐Rodriguez & Sinem K Saka
Description
Summary:Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of publications presenting novel methods for obtaining spatially resolved information for any omics data type on spatial scales ranging from subcellular to organismal. From a technology development perspective, spatial omics is a highly interdisciplinary field that integrates imaging and omics, spatial and molecular analyses, sequencing and mass spectrometry, and image analysis and bioinformatics. The emergence of this field has not only opened a window into spatial biology, but also created multiple novel opportunities, questions, and challenges for method developers. Here, we provide the perspective of technology developers on what makes the spatial omics field unique. After providing a brief overview of the state of the art, we discuss technological enablers and challenges and present our vision about the future applications and impact of this melting pot.
Item Description:Online veröffentlicht: 16. Oktober 2023
Gesehen am 20.12.2023
Physical Description:Online Resource
ISSN:1744-4292
DOI:10.15252/msb.202110571

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