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Advancing nerve regeneration: translational perspectives of tacrolimus (FK506)

Peripheral nerve injuries have far-reaching implications for individuals and society, leading to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug known for its neuroregenerative properties, has emerged in experimenta...

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Bibliographic Details
Main Authors: Däschler, Simeon C. (Author) , Feinberg, Konstantin (Author) , Harhaus-Wähner, Leila (Author) , Kneser, Ulrich (Author) , Gordon, Tessa (Author) , Borschel, Gregory H. (Author)
Format: Article (Journal)
Language:English
Published: 14 August 2023
In: International journal of molecular sciences
Year: 2023, Volume: 24, Issue: 16, Pages: 1-10
ISSN:1422-0067
DOI:10.3390/ijms241612771
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms241612771
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/16/12771
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Author Notes:Simeon C. Daeschler, Konstantin Feinberg, Leila Harhaus, Ulrich Kneser, Tessa Gordon, Gregory H. Borschel
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Summary:Peripheral nerve injuries have far-reaching implications for individuals and society, leading to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug known for its neuroregenerative properties, has emerged in experimental studies as a promising candidate to accelerate nerve fiber regeneration. This review investigates the therapeutic potential of tacrolimus by exploring the postulated mechanisms of action in relation to biological barriers to nerve injury recovery. By mapping both the preclinical and clinical evidence, the benefits and drawbacks of systemic tacrolimus administration and novel delivery systems for localized tacrolimus delivery after nerve injury are elucidated. Through synthesizing the current evidence, identifying practical barriers for clinical translation, and discussing potential strategies to overcome the translational gap, this review provides insights into the translational perspectives of tacrolimus as an adjunct therapy for nerve regeneration.
Item Description:Gesehen am 20.12.2024
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms241612771

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