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The role of sensory innervation in homeostatic and injury-induced corneal epithelial renewal

The cornea is the window through which we see the world. Corneal clarity is required for vision, and blindness occurs when the cornea becomes opaque. The cornea is covered by unique transparent epithelial cells that serve as an outermost cellular barrier bordering between the cornea and the external...

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Main Authors: Feinberg, Konstantin (Author) , Tajdaran, Kiana (Author) , Mirmoeini, Kaveh (Author) , Däschler, Simeon C. (Author) , Henriquez, Mario A. (Author) , Stevens, Katelyn E. (Author) , Mulenga, Chilando M. (Author) , Hussain, Arif (Author) , Hamrah, Pedram (Author) , Ali, Asim (Author) , Gordon, Tessa (Author) , Borschel, Gregory H. (Author)
Format: Article (Journal)
Language:English
Published: August 2023
In: International journal of molecular sciences
Year: 2023, Volume: 24, Issue: 16, Pages: 1-16
ISSN:1422-0067
DOI:10.3390/ijms241612615
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms241612615
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/16/12615
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Author Notes:Konstantin Feinberg, Kiana Tajdaran, Kaveh Mirmoeini, Simeon C. Daeschler, Mario A. Henriquez, Katelyn E. Stevens, Chilando M. Mulenga, Arif Hussain, Pedram Hamrah, Asim Ali, Tessa Gordon, Gregory H. Borschel
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Summary:The cornea is the window through which we see the world. Corneal clarity is required for vision, and blindness occurs when the cornea becomes opaque. The cornea is covered by unique transparent epithelial cells that serve as an outermost cellular barrier bordering between the cornea and the external environment. Corneal sensory nerves protect the cornea from injury by triggering tearing and blink reflexes, and are also thought to regulate corneal epithelial renewal via unknown mechanism(s). When protective corneal sensory innervation is absent due to infection, trauma, intracranial tumors, surgery, or congenital causes, permanent blindness results from repetitive epithelial microtraumas and failure to heal. The condition is termed neurotrophic keratopathy (NK), with an incidence of 5:10,000 people worldwide. In this report, we review the currently available therapeutic solutions for NK and discuss the progress in our understanding of how the sensory nerves induce corneal epithelial renewal.
Item Description:Gesehen am 02.01.2023
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms241612615

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