The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia
Ataxia-telangiectasia (A-T) is a multisystem recessive disease characterized by cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency and increased risk of cancer. The ATM gene, responsible for A-T, was recently cloned at human chromosome band 11q22-23, a region of frequent alterations...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1998
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| In: |
British journal of haematology
Year: 1998, Volume: 103, Issue: 2, Pages: 536-538 |
| ISSN: | 1365-2141 |
| DOI: | 10.1046/j.1365-2141.1998.00993.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2141.1998.00993.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.1998.00993.x 
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| Author Notes: | Seisho Takeuchi, Michiaki Koike, Susan Park, Taku Seriu, Claus R. Bartram, Harry E. Taub, Ian K. Williamson, Jeffrey Grewal, Hirokuni Taguchi, H. Phillip Koeffler |
| Summary: | Ataxia-telangiectasia (A-T) is a multisystem recessive disease characterized by cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency and increased risk of cancer. The ATM gene, responsible for A-T, was recently cloned at human chromosome band 11q22-23, a region of frequent alterations in childhood acute lymphoblastic leukaemia (ALL). Children with A-T frequently develop T-ALL. We investigated 18 T-ALL samples for ATM mutations and loss of heterozygosity (LOH) at the ATM locus. No mutations of ATM were found within the coding region in the 18 T-ALL samples, and LOH at the ATM locus was detected in three. The ATM gene appears to be an infrequently altered tumour suppressor gene in childhood T-ALL. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 4. Januar 2002 Gesehen am 04.01.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1365-2141 |
| DOI: | 10.1046/j.1365-2141.1998.00993.x |