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The Influence of diabetes, hypertension, and hyperlipidemia on the onset of age-related macular degeneration in North China: the Kailuan Eye Study

Objective: To analyze the prevalence of dry and wet age-related macular degeneration (AMD) in patients with diabetes, hypertension and hyperlipidemia, and to analyze the risk factors for AMD. Methods: A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals....

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Main Authors: Zhang, Yong Peng (Author) , Wang, Ya Xing (Author) , Zhou, Jin Qiong (Author) , Wang, Qian (Author) , Yan, Yan Ni (Author) , Yang, Xuan (Author) , Yang, Jing Yan (Author) , Zhou, Wen Jia (Author) , Wang, Ping (Author) , Shen, Chang (Author) , Yang, Ming (Author) , Luan, Ya Nan (Author) , Wang, Jin Yuan (Author) , Wu, Shou Ling (Author) , Chen, Shuo Hua (Author) , Wang, Hai Wei (Author) , Fang, Li Jian (Author) , Wan, Qian Qian (Author) , Zhu, Jing Yuan (Author) , Nie, Zi Han (Author) , Chen, Yu Ning (Author) , Xie, Ying (Author) , Jonas, Jost B. (Author) , Wei, Wen Bin (Author)
Format: Article (Journal)
Language:English
Published: Jul. 2022
In: Biomedical and environmental sciences
Year: 2022, Volume: 35, Issue: 7, Pages: 613-621
ISSN:2214-0190
DOI:10.3967/bes2022.081
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3967/bes2022.081
Verlag, lizenzpflichtig, Volltext: https://www.besjournal.com/en/article/doi/10.3967/bes2022.081
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Author Notes:ZHANG Yong Peng, WANG Ya Xing, ZHOU Jin Qiong, Wang Qian, YAN Yan Ni, Yang Xuan, YANG Jing Yan, ZHOU Wen Jia, Wang Ping, Shen Chang, Yang Ming, LUAN Ya Nan, WANG Jin Yuan, WU Shou Ling, CHEN Shuo Hua, WANG Hai Wei, FANG Li Jian, WAN Qian Qian, ZHU Jing Yuan, NIE Zi Han, CHEN Yu Ning, XIE Ying, Jonas JB, and WEI Wen Bin
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Summary:Objective: To analyze the prevalence of dry and wet age-related macular degeneration (AMD) in patients with diabetes, hypertension and hyperlipidemia, and to analyze the risk factors for AMD. Methods: A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals. We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD. Results: The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3% and 0.5%, respectively, and the prevalence of dry AMD was 17% and 16.4%, respectively. The prevalence of wet AMD in healthy, hypertensive, hyperlipidemic, and hypertensive/hyperlipidemic populations was 0.5%, 0.3%, 0.2%, and 0.7%, respectively. The prevalence of dry AMD in healthy, hypertensive, hyperlipidemic, and hypertensive/hyperlipidemic populations was 16.6%, 16.2%, 15.2%, and 17.2%, respectively. Age, sex, body mass index, and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD. Diabetes, diabetes/hypertension, diabetes/hyperlipidemia, and diabetes/hypertension/hyperlipidemia were analyzed. None of the factors analyzed in the current study increased the risk for the onset of AMD. Conclusion: There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects. Similarly, there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia. Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD.
Item Description:Gesehen am 08.01.2024
Physical Description:Online Resource
ISSN:2214-0190
DOI:10.3967/bes2022.081

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