Cover Image

DNA adducts in urothelial cells: relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke

Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 non-smokers. DNA adducts were determined by P32-postlabeling in the exfo...

Full description

Saved in:
Bibliographic Details
Main Authors: Vineis, Paolo (Author) , Talaska, Glenn (Author) , Malaveille, Christian (Author) , Bartsch, Helmut (Author) , Martone, Tiziana (Author) , Sithisarankul, Pornchai (Author) , Strickland, Paul (Author)
Format: Article (Journal)
Language:English
Published: 26 January 1996
In: International journal of cancer
Year: 1996, Volume: 65, Issue: 3, Pages: 314-316
ISSN:1097-0215
DOI:10.1002/(SICI)1097-0215(19960126)65:3<314::AID-IJC6>3.0.CO;2-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/(SICI)1097-0215(19960126)65:3<314::AID-IJC6>3.0.CO;2-2
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291097-0215%2819960126%2965%3A3%3C314%3A%3AAID-IJC6%3E3.0.CO%3B2-2
Get full text
Author Notes:Paolo Vineis, Glenn Talaska, Christian Malaveille, Helmut Bartsch, Tiziana Martone, Pornchai Sithisarankul, Paul Strickland
Description
Summary:Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 non-smokers. DNA adducts were determined by P32-postlabeling in the exfoliated bladder cells of 39 healthy subjects. Both 1-hydroxypyrene-glucuronide (1-OHPG) and 4-aminobiphenyl adducts (4-ABP-Hb) were associated with smoking habits, but only 4-ABP-Hb adducts were associated with consumption of black, air-cured tobacco. The levels of 2 DNA adducts (numbers 2 and 4) in urothelial cells were clearly associated with 4-ABP-Hb adducts, in all subjects and in smokers. Levels of one of these DNA adducts (number 2) were also associated with 1-hydroxypyrene-glucuronide in urines, but in smokers the association was not statistically significant. Overall, these observations constitute further evidence of a role of arylamines in tobacco-induced bladder cancer. © 1996 Wiley-Liss, Inc.
Item Description:Gesehen am 09.01.2024
Physical Description:Online Resource
ISSN:1097-0215
DOI:10.1002/(SICI)1097-0215(19960126)65:3<314::AID-IJC6>3.0.CO;2-2

Similar Items