Social isolation and incident dementia in the oldest-old: a competing risk analysis
PurposeSocial isolation is considered a risk factor for dementia. However, less is known about social isolation and dementia with respect to competing risk of death, particularly in the oldest-old, who are at highest risk for social isolation, dementia and mortality. Therefore, we aimed to examine t...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 June 2022
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| In: |
Frontiers in psychiatry
Year: 2022, Jahrgang: 13, Pages: 1-11 |
| ISSN: | 1664-0640 |
| DOI: | 10.3389/fpsyt.2022.834438 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fpsyt.2022.834438 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.834438 
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| Verfasserangaben: | Jessica Grothe, Susanne Röhr, Melanie Luppa, Alexander Pabst, Luca Kleineidam, Kathrin Heser, Angela Fuchs, Michael Pentzek, Anke Oey, Birgitt Wiese, Dagmar Lühmann, Hendrik van den Bussche, Siegfried Weyerer, Jochen Werle, Dagmar Weeg, Horst Bickel, Martin Scherer, Hans-Helmut König, André Hajek, Michael Wagner and Steffi G. Riedel-Heller |
MARC
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| 245 | 1 | 0 | |a Social isolation and incident dementia in the oldest-old |b a competing risk analysis |c Jessica Grothe, Susanne Röhr, Melanie Luppa, Alexander Pabst, Luca Kleineidam, Kathrin Heser, Angela Fuchs, Michael Pentzek, Anke Oey, Birgitt Wiese, Dagmar Lühmann, Hendrik van den Bussche, Siegfried Weyerer, Jochen Werle, Dagmar Weeg, Horst Bickel, Martin Scherer, Hans-Helmut König, André Hajek, Michael Wagner and Steffi G. Riedel-Heller |
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| 520 | |a PurposeSocial isolation is considered a risk factor for dementia. However, less is known about social isolation and dementia with respect to competing risk of death, particularly in the oldest-old, who are at highest risk for social isolation, dementia and mortality. Therefore, we aimed to examine these associations in a sample of oldest-old individuals.MethodsAnalyses were based on follow-up (FU) 5-9 of the longitudinal German study AgeCoDe/AgeQualiDe. Social isolation was assessed using the short form of the Lubben Social Network Scale (LSNS-6), with a score ≤ 12 indicating social isolation. Structured interviews were used to identify dementia cases. Competing risk analysis based on the Fine-Gray model was conducted to test the association between social isolation and incident dementia.ResultsExcluding participants with prevalent dementia, n = 1,161 individuals were included. Their mean age was 86.6 (SD = 3.1) years and 67.0% were female. The prevalence of social isolation was 34.7% at FU 5, 9.7% developed dementia and 36.0% died during a mean FU time of 4.3 (SD = 0.4) years. Adjusting for covariates and cumulative mortality risk, social isolation was not significantly associated with incident dementia; neither in the total sample (sHR: 1.07, 95%CI 0.65-1.76, p = 0.80), nor if stratified by sex (men: sHR: 0.71, 95%CI 0.28-1.83, p = 0.48; women: sHR: 1.39, 95%CI 0.77-2.51, p = 0.27).ConclusionIn contrast to the findings of previous studies, we did not find an association between social isolation and incident dementia in the oldest-old. However, our analysis took into account the competing risk of death and the FU period was rather short. Future studies, especially with longer FU periods and more comprehensive assessment of qualitative social network characteristics (e.g., loneliness and satisfaction with social relationships) may be useful for clarification. | ||
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