Analysis of aneurysmal subarachnoid hemorrhage as a multistep process
Background and purpose Aneurysmal subarachnoid hemorrhage (ASAH) is a complex disease with higher incidence in women compared to men and in Japan compared to other countries. It was hypothesized that ASAH is consistent with a multistep model of disease. The following assessments were made: (1) the n...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2024
|
| In: |
European journal of neurology
Year: 2024, Volume: 31, Issue: 2, Pages: 1-3 |
| ISSN: | 1468-1331 |
| DOI: | 10.1111/ene.16118 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ene.16118 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.16118 
|
| Author Notes: | Ynte M. Ruigrok, Gabriel J.E. Rinkel, Han-Sol Chang, Katharina A.M. Hackenberg, Nima Etminan, Jan H. Veldink |
| Summary: | Background and purpose Aneurysmal subarachnoid hemorrhage (ASAH) is a complex disease with higher incidence in women compared to men and in Japan compared to other countries. It was hypothesized that ASAH is consistent with a multistep model of disease. The following assessments were made: (1) the number of steps needed for the disease to occur and (2) whether this number may be different in female versus male and in Japanese versus non-Japanese patients. Methods Incidence data were generated from a meta-analysis on ASAH incidence until 2017, which was supplemented with a literature search from 2017 to April 2023. Age- and sex-adjusted incidences per 10-year age groups were calculated and the logarithm of age-specific incidence against the logarithm of age was regressed with least-squares regression. Results In 2317 ASAH patients a linear relationship between logarithm of incidence and logarithm of age was found with a slope estimate of 3.13 (95% confidence interval 2.60-3.65), consistent with a four-step process. Similar estimates were found for female, male, Japanese and non-Japanese patients. Conclusions Our results suggest that ASAH is a four-step process, also in subgroups with higher ASAH incidence. Elucidation of the exact nature of these steps can provide important clues for identification of disease mechanisms underlying ASAH. |
|---|---|
| Item Description: | Gesehen am 19.01.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1468-1331 |
| DOI: | 10.1111/ene.16118 |