Acetazolamide reduces the erythropoietin response to hypoxia at high altitude in humans
Objective - Acetazolamide, a carbonic anhydrase inhibitor, is often used as a prophylactic drug for acute mountain sickness. It may interfere with erythropoietin production due to its action on ventilation and renal function. - Design - A randomized, double-blind, placebo-controlled trial with 2×250...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1994
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| In: |
Wilderness & environmental medicine
Year: 1994, Volume: 5, Issue: 3, Pages: 312-317 |
| ISSN: | 1545-1534 |
| DOI: | 10.1580/0953-9859-5.3.312 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1580/0953-9859-5.3.312 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S095398599471130X 
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| Author Notes: | Walter H. Reinhart, Stefan Goerre, Peter Bärtsch |
| Summary: | Objective - Acetazolamide, a carbonic anhydrase inhibitor, is often used as a prophylactic drug for acute mountain sickness. It may interfere with erythropoietin production due to its action on ventilation and renal function. - Design - A randomized, double-blind, placebo-controlled trial with 2×250mg acetazolamide daily beginning one day before ascent from 590 m to 4559 m. - Setting - High-altitude research facilities at the Capanna Regina Margherita (Italy) at an altitude of 4559 m. - Participants - Eighteen healthy volunteers, aged 24-42 years. Main outcome measure: Plasma erythropoietin was measured by radioimmunoassay before and after the ascent. - Results - The increase of erythropoietin at high altitude was smaller in the acetazolamide group (increase by 10.8±7.8 U/L or 58%) than in the placebo group (increase by 22.7±13.8 U/L or 113%, p<.01). - Conclusion - Acetazolamide reduces the erythropoietin response to hypoxia in humans, which might also have therapeutic implications in conditions such as secondary polycythemia. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 12. April 2010 Gesehen am 22.01.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1545-1534 |
| DOI: | 10.1580/0953-9859-5.3.312 |