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HLA-E and its soluble form as indicators of a sex-specific immune response in patients with rral squamous cell carcinoma

The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carc...

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Main Authors: Radermacher, Anne (Author) , Fehrenz, Michael (Author) , Bellin, Tamara (Author) , Claßen, Carolina (Author) , Möllers, Laura Christin (Author) , Struckmeier, Ann-Kristin (Author) , Wagner, Mathias (Author) , Wartenberg, Philipp (Author) , Moratin, Julius (Author) , Freudlsperger, Christian (Author) , Freier, Kolja (Author) , Horn, Dominik (Author)
Format: Article (Journal)
Language:English
Published: 24 November 2023
In: International journal of molecular sciences
Year: 2023, Volume: 24, Issue: 23, Pages: 1-13
ISSN:1422-0067
DOI:10.3390/ijms242316699
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms242316699
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/23/16699
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Author Notes:Anne Radermacher, Michael Fehrenz, Tamara Bellin, Carolina Claßen, Laura Möller, Ann-Kristin Struckmeier, Mathias Wagner, Philipp Wartenberg, Julius Moratin, Christian Freudlsperger, Kolja Freier and Dominik Horn
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Summary:The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carcinomas (OSCC) after surgical therapy. Then, serum concentration of HLA-E (sHLA-E) was quantified in a prospective cohort by enzyme-linked immunosorbent assay. High HLA-E expression was associated with advanced UICC stage (Spearman’s correlation: p = 0.002) and worse survival (Cox-regression: progression-free survival: hazard ratio (HR) 3.129, confidence range (CI) 1.443-6.787, p = 0.004; overall survival: HR 2.328, CI 1.071-5.060, p = 0.033). The sHLA-E concentration was significantly higher in the control group than in tumor group (Mann-Whitney U-test (MW-U): p = 0.021). Within the tumor group, women showed significantly higher sHLA-E levels than men (MW-U: p = 0.049). A closer look at the tumor group and the control group showed that gender-specific differences exist: while no differences in sHLA-E concentration were detectable between female subjects of tumor group and control group (MW-U: p = 0.916), male subjects of tumor group had a significantly lower sHLA-E concentration compared to those of control group (MW-U: p = 0.001). In summary, our results provide evidence for sex-specific differences in immune responses in OSCC. This fact should be considered regarding future immunotherapy regimens.
Item Description:Gesehen am 24.01.2024
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms242316699

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