Acute expression of human APOBEC3B in mice results in RNA editing and lethality

RNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The cytosine deaminase APOBEC3B is implicated in tumor evolution through DNA mutation, but whether it also functions as an RNA editing enzyme has not been studied.

Bibliographic Details

Main Authors:	Alonso de la Vega, Alicia (Author) , Temiz, Nuri Alpay (Author) , Tasakis, Rafail (Author) , Somogyi, Kalman (Author) , Salgueiro, Lorena (Author) , Zimmer, Eleni (Author) , Ramos, Maria (Author) , Díaz-Jiménez, Alberto (Author) , Chocarro, Sara (Author) , Fernández Vaquero, Mirian (Author) , Stefanovska, Bojana (Author) , Reuveni, Eli (Author) , Ben-David, Uri (Author) , Stenzinger, Albrecht (Author) , Poth, Tanja (Author) , Heikenwälder, Mathias (Author) , Papavasiliou, Nina (Author) , Harris, Reuben S. (Author) , Sotillo, Rocio (Author)
Format:	Article (Journal)
Language:	English
Published:	24 November 2023
In:	Genome biology Year: 2023, Volume: 24, Pages: 1-20
ISSN:	1474-760X
DOI:	10.1186/s13059-023-03115-4
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13059-023-03115-4
Author Notes:	Alicia Alonso de la Vega, Nuri Alpay Temiz, Rafail Tasakis, Kalman Somogyi, Lorena Salgueiro, Eleni Zimmer, Maria Ramos, Alberto Diaz-Jimenez, Sara Chocarro, Mirian Fernández-Vaquero, Bojana Stefanovska, Eli Reuveni, Uri Ben-David, Albrecht Stenzinger, Tanja Poth, Mathias Heikenwälder, Nina Papavasiliou, Reuben S. Harris and Rocio Sotillo