Development and validation of a model for postpancreatectomy hemorrhage risk
Postpancreatectomy hemorrhage (PPH) due to postoperative pancreatic fistula (POPF) is a life-threatening complication after pancreatoduodenectomy. However, there is no prediction tool for early identification of patients at high risk of late PPH.To develop and validate a prediction model for PPH.Thi...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 6, 2023
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| In: |
JAMA network open
Year: 2023, Volume: 6, Issue: 12, Pages: 1-11 |
| ISSN: | 2574-3805 |
| DOI: | 10.1001/jamanetworkopen.2023.46113 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1001/jamanetworkopen.2023.46113 Verlag, kostenfrei, Volltext: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812585 
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| Author Notes: | Emrullah Birgin, MD, Sebastian Hempel, MD, Alina Reeg, MD, Florian Oehme, MD, Annika Schnizer, MS, Johann S. Rink, MD, Matthias F. Froelich, MD, Svetlana Hetjens, DSc, Verena Plodeck, MD, Heiner Nebelung, MD, Schaima Abdelhadi, MD, Mohammad Rahbari, MD, Patrick Téoule, MD, Erik Rasbach, MD, Christoph Reissfelder, MD, Jürgen Weitz, MD, Stefan O. Schoenberg, MD, Marius Distler, MD, Nuh N. Rahbari, MD |
| Summary: | Postpancreatectomy hemorrhage (PPH) due to postoperative pancreatic fistula (POPF) is a life-threatening complication after pancreatoduodenectomy. However, there is no prediction tool for early identification of patients at high risk of late PPH.To develop and validate a prediction model for PPH.This retrospective prognostic study included consecutive patients with clinically relevant POPF who underwent pancreatoduodenectomy from January 1, 2009, to May 20, 2023, at the University Hospital Mannheim (derivation cohort), and from January 1, 2012, to May 31, 2022, at the University Hospital Dresden (validation cohort). Data analysis was performed from May 30 to July 29, 2023.Clinical and radiologic features of PPH.Accuracy of a predictive risk score of PPH. A multivariate prediction model—the hemorrhage risk score (HRS)—was established in the derivation cohort (n = 139) and validated in the validation cohort (n = 154).A total of 293 patients (187 [64%] men; median age, 69 [IQR, 60-76] years) were included. The HRS comprised 4 variables with associations: sentinel bleeding (odds ratio [OR], 35.10; 95% CI, 5.58-221.00; P < .001), drain fluid culture positive for Candida species (OR, 14.40; 95% CI, 2.24-92.20; P < .001), and radiologic proof of rim enhancement of (OR, 12.00; 95% CI, 2.08-69.50; P = .006) or gas within (OR, 12.10; 95% CI, 2.22-65.50; P = .004) a peripancreatic fluid collection. Two risk categories were identified with patients at low risk (0-1 points) and high risk (≥2 points) to develop PPH. Patients with PPH were predicted accurately in the derivation cohort (C index, 0.97) and validation cohort (C index 0.83). The need for more invasive PPH management (74% vs 34%; P < .001) and severe complications (49% vs 23%; P < .001) were more frequent in high-risk patients compared with low-risk patients.In this retrospective prognostic study, a robust prediction model for PPH was developed and validated. This tool may facilitate early identification of patients at high risk for PPH. |
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| Item Description: | Gesehen am 25.01.2024 |
| Physical Description: | Online Resource |
| ISSN: | 2574-3805 |
| DOI: | 10.1001/jamanetworkopen.2023.46113 |