Cover Image

The theranostic optimization of PSMA-GCK01 does not compromise the imaging characteristics of [99mTc]Tc-PSMA-GCK01 compared to dedicated diagnostic [99mTc]Tc-EDDA/HYNIC-iPSMA in prostate cancer

Radiolabeled PSMA-ligands play a major role in today’s nuclear medicine. Since approval of [177Lu]Lu-PSMA-617 for therapy of metastatic prostate cancer, availability of 177Lu became bottleneck of supply due to the high demand. Recently, a theranostic PSMA-ligand, PSMA-GCK01, was developed which can...

Full description

Saved in:
Bibliographic Details
Main Authors: Mamlins, Eduards (Author) , Scharbert, Lara (Author) , Cardinale, Jens (Author) , Krotov, Maria (Author) , Winter, Erik (Author) , Rathke, Hendrik (Author) , Strodel, Birgit (Author) , Ankrah, Alfred O. (Author) , Sathekge, Mike (Author) , Haberkorn, Uwe (Author) , Kratochwil, Clemens (Author) , Giesel, Frederik L. (Author)
Format: Article (Journal)
Language:English
Published: 08 December 2023
In: Molecular imaging & biology
Year: 2023, Pages: 1-9
ISSN:1860-2002
DOI:10.1007/s11307-023-01881-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11307-023-01881-y
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s11307-023-01881-y
Get full text
Author Notes:Eduards Mamlins, Lara Scharbert, Jens Cardinale, Maria Krotov, Erik Winter, Hendrik Rathke, Birgit Strodel, Alfred O. Ankrah, Mike Sathekge, Uwe Haberkorn, Clemens Kratochwil, Frederik L. Giesel
Description
Summary:Radiolabeled PSMA-ligands play a major role in today’s nuclear medicine. Since approval of [177Lu]Lu-PSMA-617 for therapy of metastatic prostate cancer, availability of 177Lu became bottleneck of supply due to the high demand. Recently, a theranostic PSMA-ligand, PSMA-GCK01, was developed which can be labeled either diagnostically with 99mTc or therapeutically with 188Re with both nuclides available from well-known generator systems. This novel tracer might aid to overcome aforementioned supply limitations. In this investigation, the biodistribution and general imaging characteristics of [99mTc]Tc-PSMA-GCK01 were compared with the diagnostic reference compound [99mTc]Tc-EDDA/HYNIC-iPSMA in patients with advanced stage prostate cancer. In addition, the binding of both ligands to PSMA was analyzed at the molecular level using molecular docking.
Item Description:Gesehen am 30.01.2024
Physical Description:Online Resource
ISSN:1860-2002
DOI:10.1007/s11307-023-01881-y

Similar Items