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Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study

AIMS: Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot s...

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Main Authors: Deubner, Nikolas Maximilian (Author) , Berliner, Dominik (Author) , Schlipp, Angela (Author) , Gelbrich, Götz (Author) , Caforio, Alida L. P. (Author) , Felix, Stephan B. (Author) , Fu, Michael (Author) , Katus, Hugo (Author) , Angermann, Christiane E. (Author) , Lohse, Martin J. (Author) , Ertl, Georg (Author) , Störk, Stefan (Author) , Jahns, Roland (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: European journal of heart failure
Year: 2010, Volume: 12, Issue: 7, Pages: 753-762
ISSN:1879-0844
DOI:10.1093/eurjhf/hfq072
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/eurjhf/hfq072
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Author Notes:Nikolas Deubner, Dominik Berliner, Angela Schlipp, Götz Gelbrich, Alida L.P. Caforio, Stephan B. Felix, Michael Fu, Hugo Katus, Christiane E. Angermann, Martin J. Lohse, Georg Ertl, Stefan Störk, and Roland Jahns on behalf of the ETiCS-Study Group
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Summary:AIMS: Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot studies have shown their prognostic significance in human 'idiopathic' cardiomyopathy. - METHODS: We recently developed a novel highly sensitive fluorescence-based functional assay to detect stimulating beta1-aabs. We will use this method to assess Etiology, Titre-Course, and effect on Survival (ETiCS) of beta1-aabs in a prospective multicentre study with serial follow-up of patients after a first acute myocarditis or myocardial infarction. Several European core laboratories will jointly study the hypothesis that both disorders may trigger autoimmune reactions leading to the generation of beta1-aabs and/or other heart-directed aabs. Further, sera from healthy controls and well-characterized patient cohorts with dilated, ischaemic, or hypertensive cardiomyopathy will be analysed retrospectively for beta1-aab prevalence, incidence, persistence, and/or clearance. - CONCLUSION: ETiCS is so far the largest clinical diagnostic study projected to address cardiac autoimmunity. It attempts to unravel the pathophysiology of cardiac autoantibody formation and persistence/clearance. ETiCS will enhance current knowledge on autoimmunity in human heart disease and promote endeavours to develop novel therapies targeting cardiac aabs.
Item Description:Online publish-ahead-of-print 21 May 2010
Gesehen am 31.01.2024
Physical Description:Online Resource
ISSN:1879-0844
DOI:10.1093/eurjhf/hfq072

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