Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study
AIMS: Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot s...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010
|
| In: |
European journal of heart failure
Year: 2010, Volume: 12, Issue: 7, Pages: 753-762 |
| ISSN: | 1879-0844 |
| DOI: | 10.1093/eurjhf/hfq072 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/eurjhf/hfq072
|
| Author Notes: | Nikolas Deubner, Dominik Berliner, Angela Schlipp, Götz Gelbrich, Alida L.P. Caforio, Stephan B. Felix, Michael Fu, Hugo Katus, Christiane E. Angermann, Martin J. Lohse, Georg Ertl, Stefan Störk, and Roland Jahns on behalf of the ETiCS-Study Group |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1879660210 | ||
| 003 | DE-627 | ||
| 005 | 20240311115838.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240131s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/eurjhf/hfq072 |2 doi | |
| 035 | |a (DE-627)1879660210 | ||
| 035 | |a (DE-599)KXP1879660210 | ||
| 035 | |a (OCoLC)1425872663 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Deubner, Nikolas Maximilian |d 1978- |e VerfasserIn |0 (DE-588)136540589 |0 (DE-627)584499272 |0 (DE-576)301072477 |4 aut | |
| 245 | 1 | 0 | |a Cardiac beta1-adrenoceptor autoantibodies in human heart disease |b rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study |c Nikolas Deubner, Dominik Berliner, Angela Schlipp, Götz Gelbrich, Alida L.P. Caforio, Stephan B. Felix, Michael Fu, Hugo Katus, Christiane E. Angermann, Martin J. Lohse, Georg Ertl, Stefan Störk, and Roland Jahns on behalf of the ETiCS-Study Group |
| 264 | 1 | |c 2010 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online publish-ahead-of-print 21 May 2010 | ||
| 500 | |a Gesehen am 31.01.2024 | ||
| 520 | |a AIMS: Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot studies have shown their prognostic significance in human 'idiopathic' cardiomyopathy. - METHODS: We recently developed a novel highly sensitive fluorescence-based functional assay to detect stimulating beta1-aabs. We will use this method to assess Etiology, Titre-Course, and effect on Survival (ETiCS) of beta1-aabs in a prospective multicentre study with serial follow-up of patients after a first acute myocarditis or myocardial infarction. Several European core laboratories will jointly study the hypothesis that both disorders may trigger autoimmune reactions leading to the generation of beta1-aabs and/or other heart-directed aabs. Further, sera from healthy controls and well-characterized patient cohorts with dilated, ischaemic, or hypertensive cardiomyopathy will be analysed retrospectively for beta1-aab prevalence, incidence, persistence, and/or clearance. - CONCLUSION: ETiCS is so far the largest clinical diagnostic study projected to address cardiac autoimmunity. It attempts to unravel the pathophysiology of cardiac autoantibody formation and persistence/clearance. ETiCS will enhance current knowledge on autoimmunity in human heart disease and promote endeavours to develop novel therapies targeting cardiac aabs. | ||
| 650 | 4 | |a Antibody Specificity | |
| 650 | 4 | |a Autoantibodies | |
| 650 | 4 | |a Autoimmunity | |
| 650 | 4 | |a Cardiomyopathy, Dilated | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunoassay | |
| 650 | 4 | |a Multicenter Studies as Topic | |
| 650 | 4 | |a Myocardial Infarction | |
| 650 | 4 | |a Myocarditis | |
| 650 | 4 | |a Myocardium | |
| 650 | 4 | |a Patient Selection | |
| 650 | 4 | |a Receptors, Adrenergic, beta-1 | |
| 650 | 4 | |a Research Design | |
| 700 | 1 | |a Berliner, Dominik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlipp, Angela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gelbrich, Götz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Caforio, Alida L. P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Felix, Stephan B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fu, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Angermann, Christiane E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lohse, Martin J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ertl, Georg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Störk, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jahns, Roland |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of heart failure |d Oxford : Wiley, 1999 |g 12(2010), 7 vom: Juli, Seite 753-762 |h Online-Ressource |w (DE-627)306658291 |w (DE-600)1500332-2 |w (DE-576)081985983 |x 1879-0844 |7 nnas |a Cardiac beta1-adrenoceptor autoantibodies in human heart disease rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study |
| 773 | 1 | 8 | |g volume:12 |g year:2010 |g number:7 |g month:07 |g pages:753-762 |g extent:10 |a Cardiac beta1-adrenoceptor autoantibodies in human heart disease rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study |
| 856 | 4 | 0 | |u https://doi.org/10.1093/eurjhf/hfq072 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240131 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 999 | |a KXP-PPN1879660210 |e 4472853809 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Nikolas Deubner, Dominik Berliner, Angela Schlipp, Götz Gelbrich, Alida L.P. Caforio, Stephan B. Felix, Michael Fu, Hugo Katus, Christiane E. Angermann, Martin J. Lohse, Georg Ertl, Stefan Störk, and Roland Jahns on behalf of the ETiCS-Study Group"]},"origin":[{"dateIssuedDisp":"2010","dateIssuedKey":"2010"}],"language":["eng"],"note":["Online publish-ahead-of-print 21 May 2010","Gesehen am 31.01.2024"],"recId":"1879660210","person":[{"given":"Nikolas Maximilian","role":"aut","display":"Deubner, Nikolas Maximilian","family":"Deubner"},{"role":"aut","given":"Dominik","family":"Berliner","display":"Berliner, Dominik"},{"family":"Schlipp","display":"Schlipp, Angela","role":"aut","given":"Angela"},{"given":"Götz","role":"aut","display":"Gelbrich, Götz","family":"Gelbrich"},{"display":"Caforio, Alida L. P.","family":"Caforio","given":"Alida L. P.","role":"aut"},{"given":"Stephan B.","role":"aut","display":"Felix, Stephan B.","family":"Felix"},{"family":"Fu","display":"Fu, Michael","role":"aut","given":"Michael"},{"family":"Katus","display":"Katus, Hugo","role":"aut","given":"Hugo"},{"role":"aut","given":"Christiane E.","family":"Angermann","display":"Angermann, Christiane E."},{"role":"aut","given":"Martin J.","family":"Lohse","display":"Lohse, Martin J."},{"given":"Georg","role":"aut","display":"Ertl, Georg","family":"Ertl"},{"family":"Störk","display":"Störk, Stefan","role":"aut","given":"Stefan"},{"display":"Jahns, Roland","family":"Jahns","given":"Roland","role":"aut"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"subtitle":"rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study","title_sort":"Cardiac beta1-adrenoceptor autoantibodies in human heart disease","title":"Cardiac beta1-adrenoceptor autoantibodies in human heart disease"}],"relHost":[{"pubHistory":["1.1999 -"],"origin":[{"publisherPlace":"Oxford ; Amsterdam [u.a.] ; Oxford [u.a.] ; Oxford","dateIssuedKey":"1999","publisher":"Oxford University Press ; Elsevier Science ; Oxford Univ. Press ; Wiley","dateIssuedDisp":"1999-"}],"recId":"306658291","note":["Gesehen am 07.01.25"],"language":["eng"],"title":[{"subtitle":"journal of the Working Group on Heart Failure of the European Society of Cardiology","title_sort":"European journal of heart failure","title":"European journal of heart failure"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["1500332-2"],"doi":["10.1002/(ISSN)1879-0844"],"eki":["306658291"],"issn":["1879-0844"]},"disp":"Cardiac beta1-adrenoceptor autoantibodies in human heart disease rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) StudyEuropean journal of heart failure","titleAlt":[{"title":"EJHF"}],"part":{"year":"2010","volume":"12","text":"12(2010), 7 vom: Juli, Seite 753-762","extent":"10","issue":"7","pages":"753-762"}}],"physDesc":[{"extent":"10 S.","noteIll":"Illustrationen"}],"id":{"doi":["10.1093/eurjhf/hfq072"],"eki":["1879660210"]}} | ||
| SRT | |a DEUBNERNIKCARDIACBET2010 | ||