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Balanced activation of coagulation and fibrinolysis after a 2-h triathlon

To examine whether exercise-induced thrombin formation is accompanied by increased in vivo plasmin formation, we measured molecular markers and neoantigens of the hemostatic system in 10 male subjects (mean 29 yr, range 19-38) before, immediately after, and 2, 8, and 21 h after a triathlon lasting 1...

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Main Authors: Bärtsch, Peter (Author) , Welsch, Bärbel (Author) , Albert, Michael (Author) , Friedmann-Bette, Birgit (Author) , Levi, Marcel (Author) , Kruithof, Egbert K. O. (Author)
Format: Article (Journal)
Language:English
Published: November 1995
In: Medicine and science in sports and exercise
Year: 1995, Volume: 27, Issue: 11, Pages: 1465-1470
ISSN:1530-0315
Online Access:Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/acsm-msse/abstract/1995/11000/balanced_activation_of_coagulation_and.1.aspx
Verlag, lizenzpflichtig, Volltext: https://pubmed.ncbi.nlm.nih.gov/8587481/
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Author Notes:Peter Bärtsch, Bärbel Welsch, Michael Albert, Birgit Friedmann, Marcel Levi, Egbert K.O. Kruithof
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Summary:To examine whether exercise-induced thrombin formation is accompanied by increased in vivo plasmin formation, we measured molecular markers and neoantigens of the hemostatic system in 10 male subjects (mean 29 yr, range 19-38) before, immediately after, and 2, 8, and 21 h after a triathlon lasting 128-163 min. Thrombin-antithrombin (TAT) complexes, fibrinopeptide A (FPA), and tissue plasminogen activator (t-PA) antigen were maximally increased immediately after exercise and decreased thereafter rapidly. Prothrombin fragment 1+2 (PTF1+2), fibrin degradation products (FbDP) and plasmin-antiplasmin (PAP) complexes rose to a similar extent 0 and 2 h after exercise and decreased thereafter. The maximal levels of PTF1 + 2, TAT, FPA, and FbDP were 1.5-, 2.1-, 1.8-, and 1.9-fold above baseline values, respectively, while t-PA antigen and PAP rose 9.9− and 10.6-fold above baseline, respectively. This investigation shows that strenuous prolonged exercise leads to a moderate activation of blood coagulation resulting in thrombin and fibrin formation which is accompanied by a greatly enhanced plasmin generation. It is concluded that the hemostatic system of healthy individuals is well kept in balance when stimulated by prolonged strenuous exercise.
Item Description:Gesehen am 05.02.2024
Physical Description:Online Resource
ISSN:1530-0315

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