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Fibroblast growth factor 23 is associated with the development of gestational diabetes mellitus: research article

Background Besides its established impact on bone and mineral metabolism, it was suggested that fibroblast growth factor 23 (FGF23) might play an important role in the pathogenesis of type 2 diabetes. The impact of FGF23 on gestational diabetes mellitus (GDM), however, is not well understood. iFGF23...

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Main Authors: Hocher, Carl-Friedrich (Author) , Chen, Xin (Author) , Zuo, Jiao (Author) , Horvathova, Katarina (Author) , Hocher, Berthold (Author) , Krämer, Bernhard (Author) , Chu, Chang (Author)
Format: Article (Journal)
Language:English
Published: 08 August 2023
In: Diabetes, metabolism research and reviews
Year: 2023, Volume: 39, Issue: 8, Pages: e3704
ISSN:1520-7560
DOI:10.1002/dmrr.3704
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/dmrr.3704
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.3704
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Author Notes:Carl-Friedrich Hocher, Xin Chen, Jiao Zuo, Katarina Horvathova, Berthold Hocher, Bernhard K Krämer, Chang Chu
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Summary:Background Besides its established impact on bone and mineral metabolism, it was suggested that fibroblast growth factor 23 (FGF23) might play an important role in the pathogenesis of type 2 diabetes. The impact of FGF23 on gestational diabetes mellitus (GDM), however, is not well understood. iFGF23 ELISAs measure the intact FGF23 molecule, whereas cFGF23 assays measure intact FGF23 as well as degradation products of FGF23. Objectives The aim of this study is to compare the association of maternal and foetal cFGF23 and iFGF23 with GDM in a German birth cohort. Methods cFGF23 and iFGF23 were analysed in 826 random mother/child pairs from the Berlin Birth Cohort. Results Mothers who developed GDM had higher concentrations of iFGF-23 compared to mothers who did not suffer from GDM (19.73 vs. 13.23 pg/mL, p < 0.0001), but not higher concentrations of cFGF-23. Multivariant regression analyses showed that gestational diabetes is associated with iFGF23 independently of confounding factors such as age, BMI, ethnic background, family history of diabetes, smoking during pregnancy, and recurrent pregnancy loss. This, however, was only seen when using an iFGF23 ELISA measuring just the full length FGF23 and not in addition FGF23 fragments. No differences in both iFGF23 and cFGF23 concentrations between the GDM and non-GDM groups were detected in cord blood samples of the offspring. Conclusions This study of a representative German birth cohort showed that maternal but not foetal iFGF23 is independently associated with GDM.
Item Description:Gesehen am 06.02.2024
Physical Description:Online Resource
ISSN:1520-7560
DOI:10.1002/dmrr.3704

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