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Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence$article

Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in chi...

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Main Authors: Choudhary, Priyanka (Author) , Monasso, Giulietta S. (Author) , Karhunen, Ville (Author) , Ronkainen, Justiina (Author) , Mancano, Giulia (Author) , Howe, Caitlin G. (Author) , Niu, Zhongzheng (Author) , Zeng, Xuehuo (Author) , Guan, Weihua (Author) , Dou, John (Author) , Feinberg, Jason I. (Author) , Mordaunt, Charles (Author) , Pesce, Giancarlo (Author) , Baïz, Nour (Author) , Alfano, Rossella (Author) , Martens, Dries S. (Author) , Wang, Congrong (Author) , Isaevska, Elena (Author) , Keikkala, Elina (Author) , Mustaniemi, Sanna (Author) , Thio, Chris H. L. (Author) , Fraszczyk, Eliza (Author) , Tobi, Elmar W. (Author) , Starling, Anne P. (Author) , Cosin-Tomas, Marta (Author) , Urquiza, Jose (Author) , Röder, Stefan (Author) , Hoang, Thanh T. (Author) , Page, Christian (Author) , Jima, Dereje D. (Author) , House, John S. (Author) , Maguire, Rachel L. (Author) , Ott, Raffael (Author) , Pawlow, Xenia (Author) , Sirignano, Lea (Author) , Zillich, Lea (Author) , Malmberg, Anni (Author) , Rauschert, Sebastian (Author) , Melton, Phillip (Author) , Gong, Tong (Author) , Karlsson, Robert (Author) , Fore, Ruby (Author) , Perng, Wei (Author) , Laubach, Zachary M. (Author) , Czamara, Darina (Author) , Sharp, Gemma (Author) , Breton, Carrie V. (Author) , Schisterman, Enrique (Author) , Yeung, Edwina (Author) , Mumford, Sunni L. (Author) , Fallin, M. Daniele (Author) , LaSalle, Janine M. (Author) , Schmidt, Rebecca J. (Author) , Bakulski, Kelly M. (Author) , Annesi-Maesano, Isabella (Author) , Heude, Barbara (Author) , Nawrot, Tim S. (Author) , Plusquin, Michelle (Author) , Ghantous, Akram (Author) , Herceg, Zdenko (Author) , Nisticò, Lorenza (Author) , Vafeiadi, Marina (Author) , Kogevinas, Manolis (Author) , Vääräsmäki, Marja (Author) , Kajantie, Eero (Author) , Snieder, Harold (Author) , Corpeleijn, Eva (Author) , Steegers-Theunissen, Regine P. M. (Author) , Yang, Ivana V. (Author) , Dabelea, Dana (Author) , Fossati, Serena (Author) , Zenclussen, Ana C. (Author) , Herberth, Gunda (Author) , Magnus, Maria (Author) , Håberg, Siri E. (Author) , London, Stephanie J. (Author) , Munthe-Kaas, Monica Cheng (Author) , Murphy, Susan K. (Author) , Hoyo, Cathrine (Author) , Ziegler, Anette-G. (Author) , Hummel, Sandra (Author) , Witt, Stephanie (Author) , Streit, Fabian (Author) , Frank, Josef (Author) , Räikkönen, Katri (Author) , Lahti, Jari (Author) , Huang, Rae-chi (Author) , Almqvist, Catarina (Author) , Hivert, Marie-France (Author) , Jaddoe, Vincent W. V. (Author) , Järvelin, Marjo-Riitta (Author) , Kantomaa, Marko (Author) , Felix, Janine F. (Author) , Sebert, Sylvain (Author)
Format: Article (Journal)
Language:English
Published: 05 December 2023
In: Molecular psychiatry
Year: 2024, Volume: 29, Issue: 2, Pages: 348-358
ISSN:1476-5578
DOI:10.1038/s41380-023-02331-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41380-023-02331-5
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41380-023-02331-5
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Author Notes:Priyanka Choudhary, Giulietta S Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H. L Thio, Eliza Fraszczyk, Elmar W Tobi, Anne P Starling, Marta Cosin-Tomas, Jose Urquiza, Stefan Röder, Thanh T Hoang, Christian Page, Dereje D Jima, John S House, Rachel L Maguire, Raffael Ott, Xenia Pawlow, Lea Sirignano, Lea Zillich, Anni Malmberg, Sebastian Rauschert, Phillip Melton, Tong Gong, Robert Karlsson, Ruby Fore, Wei Perng, Zachary M Laubach, Darina Czamara, Gemma Sharp, Carrie V Breton, Enrique Schisterman, Edwina Yeung, Sunni L Mumford, M Daniele Fallin, Janine M LaSalle, Rebecca J Schmidt, Kelly M Bakulski, Isabella Annesi-Maesano, Barbara Heude, Tim S Nawrot, Michelle Plusquin, Akram Ghantous, Zdenko Herceg, Lorenza Nisticò, Marina Vafeiadi, Manolis Kogevinas, Marja Vääräsmäki, Eero Kajantie, Harold Snieder, Eva Corpeleijn, Regine PM Steegers-Theunissen, Ivana V Yang, Dana Dabelea, Serena Fossati, Ana C Zenclussen, Gunda Herberth, Maria Magnus, Siri E Håberg, Stephanie J London, Monica Cheng Munthe-Kaas, Susan K Murphy, Cathrine Hoyo, Anette-G Ziegler, Sandra Hummel, Stephanie H Witt, Fabian Streit, Josef Frank, Katri Räikkönen, Jari Lahti, Rae-chi Huang, Catarina Almqvist, Marie-France Hivert, Vincent WV Jaddoe, Marjo-Riitta Järvelin, Marko Kantomaa, Janine F Felix and Sylvain Sebert
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Summary:Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.
Item Description:Gesehen am 07.02.2024
Physical Description:Online Resource
ISSN:1476-5578
DOI:10.1038/s41380-023-02331-5

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