Expression and significance of FXYD-3 protein in gastric adenocarcinoma
Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010
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| In: |
Disease markers
Year: 2010, Volume: 28, Pages: 63-69 |
| ISSN: | 1875-8630 |
| DOI: | 10.3233/DMA-2010-0669 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3233/DMA-2010-0669 Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/dm/2010/868037/ 
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| Author Notes: | Zhen-Long Zhu, Zeng-Ren Zhao, Yu Zhang, Yan-Hong Yang, Zheng-Min Wang, Dong-Sheng Cui, Ming-Wei Wang, Jörg Kleeff, Hany Kayed, Bao-Yong Yan and Xiao-Feng Sun |
| Summary: | Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma.Patients and methods: FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n = 29) and gastric adenocarcinoma (n = 51), obtained from surgical resection of gastric cancer patients.Results: FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X2=13.210, p < 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X2 = 5.765, p = 0.016). However, FXYD-3 expression was not correlated with patient’s gender, age, tumor size, lymph node status and histological grade (p > 0.05).Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma. |
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| Item Description: | Gesehen am 09.02.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1875-8630 |
| DOI: | 10.3233/DMA-2010-0669 |