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Expression and significance of FXYD-3 protein in gastric adenocarcinoma

Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated...

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Zhen-Long (VerfasserIn) , Zhao, Zeng-Ren (VerfasserIn) , Zhang, Yu (VerfasserIn) , Yang, Yan-Hong (VerfasserIn) , Wang, Zheng-Min (VerfasserIn) , Cui, Dong-Sheng (VerfasserIn) , Wang, Ming-Wei (VerfasserIn) , Kleeff, Jörg (VerfasserIn) , Kayed, Hany (VerfasserIn) , Yan, Bao-Yong (VerfasserIn) , Sun, Xiao-Feng (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2010
In: Disease markers
Year: 2010, Jahrgang: 28, Pages: 63-69
ISSN:1875-8630
DOI:10.3233/DMA-2010-0669
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3233/DMA-2010-0669
Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/dm/2010/868037/
Volltext
Verfasserangaben:Zhen-Long Zhu, Zeng-Ren Zhao, Yu Zhang, Yan-Hong Yang, Zheng-Min Wang, Dong-Sheng Cui, Ming-Wei Wang, Jörg Kleeff, Hany Kayed, Bao-Yong Yan and Xiao-Feng Sun
Beschreibung
Zusammenfassung:Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma.Patients and methods: FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n = 29) and gastric adenocarcinoma (n = 51), obtained from surgical resection of gastric cancer patients.Results: FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X2=13.210, p < 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X2 = 5.765, p = 0.016). However, FXYD-3 expression was not correlated with patient’s gender, age, tumor size, lymph node status and histological grade (p > 0.05).Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.
Beschreibung:Gesehen am 09.02.2024
Beschreibung:Online Resource
ISSN:1875-8630
DOI:10.3233/DMA-2010-0669

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