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Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms governing the balance between proliferation and differentiation in MBEN remain poorly understood. Here, we employ a multi-modal single cell tra...

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Main Authors: Ghasemi, David R. (Author) , Okonechnikov, Konstantin (Author) , Rademacher, Anne (Author) , Tirier, Stephan Marius (Author) , Maaß, Kendra K. (Author) , Schumacher, Hanna (Author) , Joshi, Piyush (Author) , Gold, Maxwell P. (Author) , Sundheimer, Julia (Author) , Statz, Britta (Author) , Rifaioglu, Ahmet (Author) , Bauer, Katharina (Author) , Schumacher, Sabrina (Author) , Bortolomeazzi, Michele (Author) , Giangaspero, Felice (Author) , Ernst, Kati (Author) , Clifford, Steven C. (Author) , Sáez Rodríguez, Julio (Author) , Jones, David T. W. (Author) , Kawauchi, Daisuke (Author) , Fraenkel, Ernest (Author) , Mallm, Jan-Philipp (Author) , Rippe, Karsten (Author) , Korshunov, Andrey (Author) , Pfister, Stefan (Author) , Pajtler, Kristian Wilfried (Author)
Format: Article (Journal)
Language:English
Published: 08 January 2024
In: Nature Communications
Year: 2024, Volume: 15, Pages: 1-20
ISSN:2041-1723
DOI:10.1038/s41467-023-44117-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-023-44117-x
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-023-44117-x
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Author Notes:David R. Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K. Maass, Hanna Schumacher, Piyush Joshi, Maxwell P. Gold, Julia Sundheimer, Britta Statz, Ahmet S. Rifaioglu, Katharina Bauer, Sabrina Schumacher, Michele Bortolomeazzi, Felice Giangaspero, Kati J. Ernst, Steven C. Clifford, Julio Saez-Rodriguez, David T.W. Jones, Daisuke Kawauchi, Ernest Fraenkel, Jan-Philipp Mallm, Karsten Rippe, Andrey Korshunov, Stefan M. Pfister, Kristian W. Pajtler
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Summary:Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms governing the balance between proliferation and differentiation in MBEN remain poorly understood. Here, we employ a multi-modal single cell transcriptome analysis to dissect this process. In the internodular compartment, we identify proliferating cerebellar granular neuronal precursor-like malignant cells, along with stromal, vascular, and immune cells. In contrast, the nodular compartment comprises postmitotic, neuronally differentiated malignant cells. Both compartments are connected through an intermediate cell stage resembling actively migrating CGNPs. Notably, we also discover astrocytic-like malignant cells, found in proximity to migrating and differentiated cells at the transition zone between the two compartments. Our study sheds light on the spatial tissue organization and its link to the developmental trajectory, resulting in a more benign tumor phenotype. This integrative approach holds promise to explore intercompartmental interactions in other cancers with varying histology.
Item Description:Gesehen am 13.02.2024
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-023-44117-x

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