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Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: proof-of-concept in borderline personality disorder: original article

Background: The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study...

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Main Authors: Zopfs, Malte (Author) , Jindrová, Miroslava (Author) , Gurevitch, Guy (Author) , Keynan, Jackob N. (Author) , Hendler, Talma (Author) , Baumeister, Sarah (Author) , Aggensteiner, Pascal (Author) , Cornelisse, Sven (Author) , Brandeis, Daniel (Author) , Schmahl, Christian (Author) , Paret, Christian (Author)
Format: Article (Journal)
Language:English
Published: 22 December 2023
In: Psychological medicine
Year: 2024, Volume: 54, Issue: 8, Pages: 1651-1660
ISSN:1469-8978
DOI:10.1017/S0033291723003549
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1017/S0033291723003549
Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/amygdalarelated-electrical-fingerprint-is-modulated-with-neurofeedback-training-and-correlates-with-deepbrain-activation-proofofconcept-in-borderline-personality-disorder/043AD253614BF893C6AAA89879E5426B
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Author Notes:Malte Zopfs, Miroslava Jindrová, Guy Gurevitch, Jackob N. Keynan, Talma Hendler, Sarah Baumeister, Pascal-M. Aggensteiner, Sven Cornelisse, Daniel Brandeis, Christian Schmahl and Christian Paret
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Summary:Background: The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation.MethodsStudy 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, N = 15 matched patients served as DBT-only controls.ResultsStudy 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results.ConclusionsRecorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated.
Item Description:Gesehen am 15.02.2024
Physical Description:Online Resource
ISSN:1469-8978
DOI:10.1017/S0033291723003549

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