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Central visual field damage in glaucoma eyes with choroidal microvasculature dropout with and without high axial myopia

Purpose To characterise the relationship between a deep-layer microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with and without high axial myopia. - Design Cross-sectional study. - Methods Seventy-one eyes (49 patients) with high axia...

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Main Authors: Micheletti, Eleonora (Author) , El-Nimri, Nevin (Author) , Nishida, Takashi (Author) , Moghimi, Sasan (Author) , Rezapour, Jasmin (Author) , Fazio, Massimo A. (Author) , Suh, Min Hee (Author) , Bowd, Christopher (Author) , Belghith, Akram (Author) , Christopher, Mark (Author) , Jonas, Jost B. (Author) , Weinreb, Robert N. (Author) , Zangwill, Linda M. (Author)
Format: Article (Journal)
Language:English
Published: February 20, 2023
In: British journal of ophthalmology
Year: 2024, Volume: 108, Issue: 3, Pages: 372-379
ISSN:1468-2079
DOI:10.1136/bjo-2022-322234
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bjo-2022-322234
Verlag, lizenzpflichtig, Volltext: https://bjo.bmj.com/content/early/2023/02/19/bjo-2022-322234
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Author Notes:Eleonora Micheletti, Nevin El-Nimri, Takashi Nishida, Sasan Moghimi, Jasmin Rezapour, Massimo A Fazio, Min Hee Suh, Christopher Bowd, Akram Belghith, Mark Christopher, Jost B Jonas, Robert N Weinreb, Linda M Zangwill
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Summary:Purpose To characterise the relationship between a deep-layer microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with and without high axial myopia. - Design Cross-sectional study. - Methods Seventy-one eyes (49 patients) with high axial myopia and POAG and 125 non-highly myopic POAG eyes (97 patients) were enrolled. Presence, area and angular circumference of juxtapapillary MvD were evaluated on optical coherence tomography angiography B-scans and en-face choroidal images. - Results Juxtapapillary MvD was detected more often in the highly myopic POAG eyes (43 eyes, 86%) than in the non-highly myopic eyes (73 eyes, 61.9%; p=0.002). In eyes with MvD, MvD area and angular circumference (95% CI) were significantly larger in the highly myopic eyes compared with the non-highly myopic eyes (area: (0.69 (0.40, 0.98) mm2 vs 0.31 (0.19, 0.42) mm2, p=0.011) and (angular circumference: 84.3 (62.9, 105.8) vs 74.5 (58.3, 90.9) degrees, p<0.001), respectively. 24-2 VF mean deviation (MD) was significantly worse in eyes with MvD compared with eyes without MvD in both groups (p<0.001). After adjusting for 24-2 MD VF, central VF defects were more frequently found in eyes with MvD compared with eyes without MvD (82.7% vs 60.9%, p<0.001). In multivariable analysis, higher intraocular pressure, worse 24-2 VF MD, longer axial length and greater MvD area and angular circumference were associated with worse 10-2 VF MD. - Conclusions MvD was more prevalent and larger in POAG eyes with high myopia than in non-highly myopic POAG eyes. In both groups, eyes with MvD showed worse glaucoma severity and more central VF defects.
Item Description:Zu diesem Artikel gibt es Supplementary Material (2 Seiten)
Gesehen am 15.02.2024
Physical Description:Online Resource
ISSN:1468-2079
DOI:10.1136/bjo-2022-322234

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