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Mask continuous positive airway pressure increases diaphragm thickening fraction in healthy subjects

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Introduction: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory s...

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Main Authors: Lindner, Simon (Author) , Teichert, Jan (Author) , Hoermann, Clara (Author) , Michels-Zetsche, Julia D. (Author) , Herth, Felix (Author) , Dürschmied, Daniel (Author) , Britsch, Simone (Author)
Format: Article (Journal)
Language:English
Published: February 2024
In: Respiration
Year: 2024, Volume: 103, Issue: 2, Pages: 100-104
ISSN:1423-0356
DOI:10.1159/000535990
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000535990
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Author Notes:Simon Lindner, Jan Teichert, Clara Hoermann, Julia D. Michels, Felix J.F. Herth, Daniel Duerschmied, Simone Britsch
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Summary:Introduction: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. Methods: DTF was measured in spontaneously breathing, healthy volunteers during 4 phases: (I) without connection to a ventilator, (II) on a ventilator without any applied pressures, (III) with a CPAP of 5 cmH2O, and (IV) with an additional inspiratory support pressure of 5 cmH2O. Results: Twenty-nine individuals agreed to participate. DTF was similar during the first two phases (32 ± 13% and 35 ± 22%). A considerable increase in DTF to 51 ± 21% was noted in phase III. The introduction of inspiratory support pressure during phase IV led to a reduction in DTF back to 36 ± 23% (p < 0.001). Tidal volume and minute ventilation were both slightly higher in phase IV compared to phase III. Conclusion: CPAP without inspiratory support pressure increases respiratory effort measured by DTF in healthy subjects. Further research is required to investigate this phenomenon in a clinical setting.
Item Description:Online veröffentlicht: 16. Januar 2024
Gesehen am 20.02.2024
Physical Description:Online Resource
ISSN:1423-0356
DOI:10.1159/000535990

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