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Relationship of Ki-67 index in biopsies of metastatic breast cancer tissue and circulating tumor cells (CTCs) at the time of biopsy collection

The proliferation marker Ki-67 is a major pathological feature for the description of the state of disease in breast cancer. It helps to define the molecular subtype and to stratify between therapy regimens in early breast cancer and helps to assess the therapy response. Circulating tumor cells (CTC...

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Main Authors: Deutsch, Thomas M. (Author) , Fischer, Chiara (Author) , Riedel, Fabian (Author) , Haßdenteufel, Kathrin (Author) , Michel, Laura L. (Author) , Sütterlin, Marc (Author) , Riethdorf, Sabine (Author) , Pantel, Klaus (Author) , Wallwiener, Markus (Author) , Schneeweiss, Andreas (Author) , Stefanovic, Stefan (Author)
Format: Article (Journal)
Language:English
Published: January 2024
In: Archives of gynecology and obstetrics
Year: 2024, Volume: 309, Issue: 1, Pages: 235-248
ISSN:1432-0711
DOI:10.1007/s00404-023-07080-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00404-023-07080-y
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Author Notes:Thomas M. Deutsch, Chiara Fischer, Fabian Riedel, Kathrin Haßdenteufel, Laura L. Michel, Marc Sütterlin, Sabine Riethdorf, Klaus Pantel, Markus Wallwiener, Andreas Schneeweiss, Stefan Stefanovic
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Summary:The proliferation marker Ki-67 is a major pathological feature for the description of the state of disease in breast cancer. It helps to define the molecular subtype and to stratify between therapy regimens in early breast cancer and helps to assess the therapy response. Circulating tumor cells (CTCs) are a negative prognostic biomarker for progression free (PFS) and overall survival (OS) in patients with metastatic breast cancer. Therefore, the CTC count is often described as surrogate for the tumor burden. Both, decrease of Ki-67 and CTC count are considered as evidence for therapy response. The presented work analyzed the correlation between the Ki-67 indices of metastatic tissue biopsies and CTC counts in biopsy time-adjacent peripheral blood samples.
Item Description:Online veröffentlicht: 22. Juli 2023
Gesehen am 20.02.2024
Physical Description:Online Resource
ISSN:1432-0711
DOI:10.1007/s00404-023-07080-y

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