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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial: research article

Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM tre...

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Main Authors: Koch, Elias A. T. (Author) , Petzold, Anne (Author) , Wessely, Anja (Author) , Dippel, Edgar (Author) , Eckstein, Markus (Author) , Gesierich, Anja (Author) , Gutzmer, Ralf (Author) , Hassel, Jessica C. (Author) , Knorr, Harald (Author) , Kreuzberg, Nicole (Author) , Leiter, Ulrike (Author) , Loquai, Carmen (Author) , Meier, Friedegund (Author) , Meissner, Markus (Author) , Mohr, Peter (Author) , Pföhler, Claudia (Author) , Rahimi, Farnaz (Author) , Schadendorf, Dirk (Author) , Schlaak, Max Simon (Author) , Thoms, Kai-Martin (Author) , Ugurel, Selma (Author) , Utikal, Jochen (Author) , Weichenthal, Michael (Author) , Schuler-Thurner, Beatrice (Author) , Berking, Carola (Author) , Heppt, Markus V. (Author)
Format: Article (Journal)
Language:English
Published: October 2023
In: Frontiers of medicine
Year: 2023, Volume: 17, Issue: 5, Pages: 878-888
ISSN:2095-0225
DOI:10.1007/s11684-023-0993-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11684-023-0993-y
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Author Notes:Elias AT Koch, Anne Petzold, Anja Wessely, Edgar Dippel, Markus Eckstein, Anja Gesierich, Ralf Gutzmer, Jessica C. Hassel, Harald Knorr, Nicole Kreuzberg, Ulrike Leiter, Carmen Loquai, Friedegund Meier, Markus Meissner, Peter Mohr, Claudia Pföhler, Farnaz Rahimi, Dirk Schadendorf, Max Schlaak, Kai-Martin Thoms, Selma Ugurel, Jochen Utikal, Michael Weichenthal, Beatrice Schuler-Thurner, Carola Berking & Markus V Heppt
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Summary:Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.
Item Description:Online veröffentlicht: 4. Juli 2023
Gesehen am 21.02.2024
Physical Description:Online Resource
ISSN:2095-0225
DOI:10.1007/s11684-023-0993-y

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