Cover Image

Fat embolism syndrome in Duchenne muscular dystrophy: report on a novel case and systematic literature review

We report a non-ambulatory 13-year-old boy with Duchenne muscular dystrophy who experienced severe acute respiratory distress syndrome and cerebral fat embolism following elective soft tissue surgery. Post-surgery radiological examination revealed bilateral femoral fractures and marked osteopenia th...

Full description

Saved in:
Bibliographic Details
Main Authors: Specht, Sabine (Author) , Zhukova, Irina (Author) , Westhoff, Jens (Author) , Erb, Larissa Diana (Author) , Ziegler, Andreas (Author) , Kölker, Stefan (Author) , Hoffmann, Georg F. (Author) , Hagmann, Sébastien (Author) , Syrbe, Steffen (Author)
Format: Article (Journal)
Language:English
Published: January 2024
In: European journal of paediatric neurology
Year: 2024, Volume: 48, Pages: 91-100
ISSN:1532-2130
DOI:10.1016/j.ejpn.2023.11.012
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejpn.2023.11.012
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1090379823001824
Get full text
Author Notes:Sabine Specht, Irina Zhukova, Jens H. Westhoff, Larissa Erb, Andreas Ziegler, Stefan Kölker, Georg F. Hoffmann, Sébastien Hagmann, Steffen Syrbe
Description
Summary:We report a non-ambulatory 13-year-old boy with Duchenne muscular dystrophy who experienced severe acute respiratory distress syndrome and cerebral fat embolism following elective soft tissue surgery. Post-surgery radiological examination revealed bilateral femoral fractures and marked osteopenia that were believed to have caused disseminated pulmonary and cerebral fat embolism. The patient had never been on glucocorticoid treatment. Five months post-surgery, he remained in a state of minimal consciousness. A literature review was performed and eleven publications included, providing case reports of a total number of 23 patients with Duchenne muscular dystrophy with fat embolism syndrome. The most common causes were falls from the wheelchair that predominantly resulted in femoral fractures. Median age at the event was around 14 years. Seven patients succumbed to complications of fat embolism. No event was described in the context of surgery. We want to raise awareness that spontaneous unnoticed fractures may occur especially in adolescents with DMD from traumatic injury of large bones and also during elective surgery with a high risk of causing fat embolism with severe sequelae.
Item Description:Online verfügbar: 6. Dezember 2023, Artikelversion: 13. Dezember 2023
Gesehen am 23.02.2024
Physical Description:Online Resource
ISSN:1532-2130
DOI:10.1016/j.ejpn.2023.11.012

Similar Items