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HPV-associated head and neck cancer is characterized by distinct profiles of CD8+ T cells and myeloid-derived suppressor cells

Patients with HPV−-localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune p...

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Main Authors: Kansy, Benjamin Alexander (Author) , Wehrs, Tim P. (Author) , Bruderek, Kirsten (Author) , Si, Yu (Author) , Ludwig, Sonja (Author) , Droege, Freya (Author) , Haßkamp, Pia (Author) , Henkel, Uta (Author) , Dominas, Nina Tatjana Maria (Author) , Hoffmann, Thomas K. (Author) , Horn, Peter A. (Author) , Schuler, Martin (Author) , Gauler, Thomas C. (Author) , Lindemann, Monika (Author) , Lang, Stephan (Author) , Bánkfalvi, Ágnes (Author) , Brandau, Sven (Author)
Format: Article (Journal)
Language:English
Published: 29 November 2023
In: Cancer immunology immunotherapy
Year: 2023, Volume: 72, Issue: 12, Pages: 4367-4383
ISSN:1432-0851
DOI:10.1007/s00262-023-03571-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00262-023-03571-8
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Author Notes:Benjamin A. Kansy, Tim P. Wehrs, Kirsten Bruderek, Yu Si, Sonja Ludwig, Freya Droege, Pia Hasskamp, Uta Henkel, Nina Dominas, Thomas K. Hoffmann, Peter A. Horn, Martin Schuler, Thomas C. Gauler, Monika Lindemann, Stephan Lang, Agnes Bankfalvi, Sven Brandau
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Summary:Patients with HPV−-localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune profiles of CD8+ T cells and myeloid-derived suppressor cells (MDSC) in HPV+ versus HPV− disease.
Item Description:Im Titel ist das Pluszeichen hochgestellt
Gesehen am 26.02.2024
Physical Description:Online Resource
ISSN:1432-0851
DOI:10.1007/s00262-023-03571-8

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