The effect of cytokine adsorption on leukocyte and platelet activation after extracorporeal cardiopulmonary resuscitation
Background: Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS is characterized by an excessive inflammatory response to whole-body ischemia and reperfusion. Cytokine adsorption was suggested as an...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10. Januar 2024
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| In: |
Thrombosis and haemostasis
Year: 2024, Pages: ? |
| ISSN: | 2567-689X |
| DOI: | 10.1055/a-2225-5173 |
| Online Access: | lizenzpflichtig lizenzpflichtig 
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| Author Notes: | Timm Zahn, Nancy Schanze, Dawid L. Staudacher, Tobias Wengenmayer, Sven Maier, Christoph Benk, Nadine Gauchel, Daniel Duerschmied, Alexander Supady |
| Summary: | Background: Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS is characterized by an excessive inflammatory response to whole-body ischemia and reperfusion. Cytokine adsorption was suggested as an adjunctive treatment option for the removal of cytokines from the patients' blood to restore the physiological equilibrium of pro- and anti-inflammatory activity and thus mitigate hemodynamic instability and end-organ complications. Material and Methods: To better understand the cellular effects of cytokine adsorption in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) after in- and out-of-hospital cardiac arrest, we compared the activation status of neutrophils, monocytes, and platelets as well as the formation of platelet-leukocyte complexes in intravenous whole blood samples from an exploratory subgroup (n = 24) from the randomized CYTER study. Result: At 48 hours after initiation of ECPR, flow cytometry analyses did neither reveal significant differences in neutrophil (CD11b, CD66b, L-selectin, and PSGL-1) and monocyte (CD11b, L-selectin, and PSGL-1) surface molecule expression nor in circulating platelet-monocyte complexes between patients receiving cytokine adsorption and those without. Conclusion: Data did not show a relevant effect of cytokine adsorption on neutrophil and monocyte activation during the first 48 hours after initiation of ECPR. |
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| Item Description: | Gesehen am 26.02.2024 |
| Physical Description: | Online Resource |
| ISSN: | 2567-689X |
| DOI: | 10.1055/a-2225-5173 |