Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation
Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 May 2010
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| In: |
Journal of neuroinflammation
Year: 2010, Volume: 7, Pages: 1-8 |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/1742-2094-7-30 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1742-2094-7-30
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| Author Notes: | Henrik Wilms, Jobst Sievers, Uta Rickert, Martin Rostami-Yazdi, Ulrich Mrowietz and Ralph Lucius |
| Summary: | Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the effector cells of neuroinflammation; however, little is known of the effect of DMF on microglia and astrocytes. The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation. |
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| Item Description: | Gesehen am 26.02.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/1742-2094-7-30 |