Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation
Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 May 2010
|
| In: |
Journal of neuroinflammation
Year: 2010, Volume: 7, Pages: 1-8 |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/1742-2094-7-30 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1742-2094-7-30
|
| Author Notes: | Henrik Wilms, Jobst Sievers, Uta Rickert, Martin Rostami-Yazdi, Ulrich Mrowietz and Ralph Lucius |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1881617459 | ||
| 003 | DE-627 | ||
| 005 | 20240311115445.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240226s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/1742-2094-7-30 |2 doi | |
| 035 | |a (DE-627)1881617459 | ||
| 035 | |a (DE-599)KXP1881617459 | ||
| 035 | |a (OCoLC)1185960672 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wilms, Henrik |d 1971- |e VerfasserIn |0 (DE-588)115836667 |0 (DE-627)077503104 |0 (DE-576)290105099 |4 aut | |
| 245 | 1 | 0 | |a Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation |c Henrik Wilms, Jobst Sievers, Uta Rickert, Martin Rostami-Yazdi, Ulrich Mrowietz and Ralph Lucius |
| 246 | 3 | 3 | |a Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1Beta, TNF-Alpha and IL-6 in an in-vitro model of brain inflammation |
| 264 | 1 | |c 19 May 2010 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.02.2024 | ||
| 520 | |a Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the effector cells of neuroinflammation; however, little is known of the effect of DMF on microglia and astrocytes. The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation. | ||
| 650 | 4 | |a Experimental Autoimmune Encephalomyelitis | |
| 650 | 4 | |a Microglial Cell | |
| 650 | 4 | |a Multiple Sclerosis | |
| 650 | 4 | |a Natalizumab | |
| 650 | 4 | |a Nitric Oxide | |
| 700 | 1 | |a Sievers, Jobst |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rickert, Uta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rostami-Yazdi, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mrowietz, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lucius, Ralph |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuroinflammation |d London : BioMed Central, 2004 |g 7(2010), Artikel-ID 30, Seite 1-8 |h Online-Ressource |w (DE-627)391784781 |w (DE-600)2156455-3 |w (DE-576)12192985X |x 1742-2094 |7 nnas |a Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation |
| 773 | 1 | 8 | |g volume:7 |g year:2010 |g elocationid:30 |g pages:1-8 |g extent:8 |a Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation |
| 856 | 4 | 0 | |u https://doi.org/10.1186/1742-2094-7-30 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240226 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 115836667 |a Wilms, Henrik |m 115836667:Wilms, Henrik |d 910000 |d 911100 |e 910000PW115836667 |e 911100PW115836667 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1881617459 |e 4491433917 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1881617459","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 26.02.2024"],"titleAlt":[{"title":"Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1Beta, TNF-Alpha and IL-6 in an in-vitro model of brain inflammation"}],"person":[{"family":"Wilms","given":"Henrik","display":"Wilms, Henrik","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Sievers, Jobst","roleDisplay":"VerfasserIn","given":"Jobst","family":"Sievers"},{"role":"aut","display":"Rickert, Uta","roleDisplay":"VerfasserIn","given":"Uta","family":"Rickert"},{"given":"Martin","family":"Rostami-Yazdi","role":"aut","roleDisplay":"VerfasserIn","display":"Rostami-Yazdi, Martin"},{"family":"Mrowietz","given":"Ulrich","display":"Mrowietz, Ulrich","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Lucius, Ralph","roleDisplay":"VerfasserIn","role":"aut","family":"Lucius","given":"Ralph"}],"title":[{"title_sort":"Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation","title":"Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation"}],"relHost":[{"title":[{"subtitle":"JNI","title":"Journal of neuroinflammation","title_sort":"Journal of neuroinflammation"}],"pubHistory":["1.2004 -"],"part":{"text":"7(2010), Artikel-ID 30, Seite 1-8","volume":"7","extent":"8","year":"2010","pages":"1-8"},"titleAlt":[{"title":"JNI"}],"note":["Gesehen am 12.07.10"],"disp":"Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammationJournal of neuroinflammation","type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"391784781","language":["eng"],"origin":[{"publisherPlace":"London","dateIssuedKey":"2004","publisher":"BioMed Central","dateIssuedDisp":"2004-"}],"id":{"zdb":["2156455-3"],"eki":["391784781"],"issn":["1742-2094"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"8 S.","noteIll":"Illustrationen, Diagramme"}],"name":{"displayForm":["Henrik Wilms, Jobst Sievers, Uta Rickert, Martin Rostami-Yazdi, Ulrich Mrowietz and Ralph Lucius"]},"id":{"doi":["10.1186/1742-2094-7-30"],"eki":["1881617459"]},"origin":[{"dateIssuedDisp":"19 May 2010","dateIssuedKey":"2010"}]} | ||
| SRT | |a WILMSHENRIDIMETHYLFU1920 | ||