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Prognosis of atrial fibrillation in patients with symptomatic peripheral arterial disease: data from the REduction of Atherothrombosis for Continued Health (REACH) registry

Background - Atrial fibrillation (AF) is a significant risk factor for cardiovascular (CV) mortality. This study aims to evaluate the prognostic implication of AF in patients with peripheral arterial disease (PAD). - Methods - The International Reduction of Atherothrombosis for Continued Health (REA...

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Main Authors: Winkel, Tamara A. (Author) , Hoeks, S. E. (Author) , Schouten, O. (Author) , Zeymer, Uwe (Author) , Limbourg, Tobias (Author) , Baumgartner, I. (Author) , Bhatt, D. L. (Author) , Steg, Ph. G. (Author) , Goto, S. (Author) , Röther, J. (Author) , Cacoub, P. P. (Author) , Verhagen, H. J. M. (Author) , Bax, J. J. (Author) , Poldermans, D. (Author)
Format: Article (Journal)
Language:English
Published: July 2010
In: European journal of vascular and endovascular surgery
Year: 2010, Volume: 40, Issue: 1, Pages: 9-16
ISSN:1532-2165
DOI:10.1016/j.ejvs.2010.03.003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejvs.2010.03.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1078588410001528
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Author Notes:T.A. Winkel, S.E. Hoeks, O. Schouten, U. Zeymer, T. Limbourg, I. Baumgartner, D.L. Bhatt, Ph. G. Steg, S. Goto, J. Röther, P.P. Cacoub, H.J.M. Verhagen, J.J. Bax, D. Poldermans
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Summary:Background - Atrial fibrillation (AF) is a significant risk factor for cardiovascular (CV) mortality. This study aims to evaluate the prognostic implication of AF in patients with peripheral arterial disease (PAD). - Methods - The International Reduction of Atherothrombosis for Continued Health (REACH) Registry included 23,542 outpatients in Europe with established coronary artery disease, cerebrovascular disease (CVD), PAD and/or ≥3 risk factors. Of these, 3753 patients had symptomatic PAD. CV risk factors were determined at baseline. Study end point was a combination of cardiac death, non-fatal myocardial infarction (MI) and stroke (CV events) during 2 years of follow-up. Cox regression analysis adjusted for age, gender and other risk factors (i.e., congestive heart failure, coronary artery re-vascularisation, coronary artery bypass grafting (CABG), MI, hypertension, stroke, current smoking and diabetes) was used. - Results - Of 3753 PAD patients, 392 (10%) were known to have AF. Patients with AF were older and had a higher prevalence of CVD, diabetes and hypertension. Long-term CV mortality occurred in 5.6% of patients with AF and in 1.6% of those without AF (p<0.001). Multivariable analyses showed that AF was an independent predictor of late CV events (hazard ratio (HR): 1.5; 95% confidence interval (CI): 1.09-2.0). - Conclusion - AF is common in European patients with symptomatic PAD and is independently associated with a worse 2-year CV outcome.
Item Description:Available online 10 April 2010
Gesehen am 26.02.2024
Physical Description:Online Resource
ISSN:1532-2165
DOI:10.1016/j.ejvs.2010.03.003

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