Cover Image

Efficient single copy integration via homology-directed repair (scHDR) by 5′modification of large DNA donor fragments in mice

Show other versions (1)

CRISPR/Cas-based approaches have largely replaced conventional gene targeting strategies. However, homology-directed repair (HDR) in the mouse genome is not very efficient, and precisely inserting longer sequences using HDR remains challenging given that donor constructs preferentially integrate as...

Full description

Saved in:
Bibliographic Details
Main Authors: Medert, Rebekka (Author) , Thumberger, Thomas (Author) , Tavhelidse-Suck, Tinatini (Author) , Hub, Tobias (Author) , Kellner, Tanja (Author) , Oguchi, Yoko (Author) , Dlugosz, Sascha (Author) , Zimmermann, Frank (Author) , Wittbrodt, Joachim (Author) , Freichel, Marc (Author)
Format: Article (Journal)
Language:English
Published: 22 February 2023
In: Nucleic acids research
Year: 2023, Volume: 51, Issue: 3, Pages: 1-14
ISSN:1362-4962
DOI:10.1093/nar/gkac1150
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/nar/gkac1150
Get full text
Author Notes:Rebekka Medert, Thomas Thumberger, Tinatini Tavhelidse-Suck, Tobias Hub, Tanja Kellner, Yoko Oguchi, Sascha Dlugosz, Frank Zimmermann, Joachim Wittbrodt and Marc Freichel
Search Result 1
Cover Image

Efficient single copy integration via homology-directed repair (scHDR) by 5’modification of large DNA donor fragments in mice by Medert, Rebekka (Author) , Thumberger, Thomas (Author) , Tavhelidse-Suck, Tinatini (Author) , Hub, Tobias (Author) , Kellner, Tanja (Author) , Oguchi, Yoko (Author) , Dlugosz, Sascha (Author) , Zimmermann, Frank (Author) , Wittbrodt, Joachim (Author) , Freichel, Marc (Author) ,


Get full text
Article (Journal) Chapter/Article Online Resource

Saved in:
Show all versions (2)

Similar Items