Microenvironmental signals shaping NK-cell reactivity in cancer: review
Since the postulation of the “missing-self” concept, much progress has been made in defining requirements for NK-cell activation. Unlike T lymphocytes that process signals from receptors in a hierarchic manner dominated by the T-cell receptors, NK cells integrate receptor signals more “democraticall...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 2023
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| In: |
European journal of immunology
Year: 2023, Volume: 53, Issue: 12 |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.202250103 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/eji.202250103 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250103 
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| Author Notes: | Bianca M. Balzasch and Adelheid Cerwenka |
| Summary: | Since the postulation of the “missing-self” concept, much progress has been made in defining requirements for NK-cell activation. Unlike T lymphocytes that process signals from receptors in a hierarchic manner dominated by the T-cell receptors, NK cells integrate receptor signals more “democratically.” Signals originate not only the downstream of cell-surface receptors triggered by membrane-bound ligands or cytokines, but are also mediated by specialized microenvironmental sensors that perceive the cellular surrounding by detecting metabolites or the availability of oxygen. Thus, NK-cell effector functions are driven in an organ and disease-dependent manner. Here, we review the latest findings on how NK-cell reactivity in cancer is determined by the reception and integration of complex signals. Finally, we discuss how this knowledge can be exploited to guide novel combinatorial approaches for NK-cell-based anticancer therapies. |
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| Item Description: | Online veröffentlicht: 17. Mai 2023 Gesehen am 27.02.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.202250103 |