Cover Image

Pharmacological, toxicological and phytochemical analysis of Spondias dulcis parkinson

Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolyti...

Full description

Saved in:
Bibliographic Details
Main Authors: Alencar Fernandes, Felipe Hugo (Author) , Soares, Sabrina (Author) , Bekbolatova, Elmira (Author) , Boylan, Fábio (Author) , Salgado, Hérida Regina Nunes (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: Natural product research
Year: 2024, Volume: 38, Issue: 6, Pages: 1049-1053
ISSN:1478-6427
DOI:10.1080/14786419.2023.2210254
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/14786419.2023.2210254
Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.1080/14786419.2023.2210254
Get full text
Author Notes:Felipe Hugo Alencar Fernandes, Sabrina da Silva Soares, Elmira Bekbolatova, Fábio Boylan, Hérida Regina Nunes Salgado
Description
Summary:Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolytic and enzymatic inhibitor. This study aimed to: (1) establish the pharmacological activity in intestinal motility in vivo and antioxidant activity in vitro; (2) perform the acute toxicology test in mouse; (3) characterize the phytochemical profile based on counter-current chromatography (CCC) and NMR analysis. The results revealed a laxative effect of S. dulcis extract and a high antioxidant activity (IC50 = 5.10 for DPPH assay and 14.14 for hydrogen peroxide scavenging test). No side effects were observed in the oral acute toxicity test for a dose up to 2000 mg/kg. The chemical profile was identified by CCC and NMR, and the comparison of the data obtained with previous literature revealed the presence of the flavonoid rutin (Quercetin-3-O-rutinoside) in the extract.
Item Description:Online veröffentlicht: 8. Mai 2023
Gesehen am 28.02.2024
Physical Description:Online Resource
ISSN:1478-6427
DOI:10.1080/14786419.2023.2210254

Similar Items