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Pharmacological, toxicological and phytochemical analysis of Spondias dulcis parkinson

Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolyti...

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Hauptverfasser: Alencar Fernandes, Felipe Hugo (VerfasserIn) , Soares, Sabrina (VerfasserIn) , Bekbolatova, Elmira (VerfasserIn) , Boylan, Fábio (VerfasserIn) , Salgado, Hérida Regina Nunes (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2024
In: Natural product research
Year: 2024, Jahrgang: 38, Heft: 6, Pages: 1049-1053
ISSN:1478-6427
DOI:10.1080/14786419.2023.2210254
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/14786419.2023.2210254
Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.1080/14786419.2023.2210254
Volltext
Verfasserangaben:Felipe Hugo Alencar Fernandes, Sabrina da Silva Soares, Elmira Bekbolatova, Fábio Boylan, Hérida Regina Nunes Salgado
Beschreibung
Zusammenfassung:Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolytic and enzymatic inhibitor. This study aimed to: (1) establish the pharmacological activity in intestinal motility in vivo and antioxidant activity in vitro; (2) perform the acute toxicology test in mouse; (3) characterize the phytochemical profile based on counter-current chromatography (CCC) and NMR analysis. The results revealed a laxative effect of S. dulcis extract and a high antioxidant activity (IC50 = 5.10 for DPPH assay and 14.14 for hydrogen peroxide scavenging test). No side effects were observed in the oral acute toxicity test for a dose up to 2000 mg/kg. The chemical profile was identified by CCC and NMR, and the comparison of the data obtained with previous literature revealed the presence of the flavonoid rutin (Quercetin-3-O-rutinoside) in the extract.
Beschreibung:Online veröffentlicht: 8. Mai 2023
Gesehen am 28.02.2024
Beschreibung:Online Resource
ISSN:1478-6427
DOI:10.1080/14786419.2023.2210254

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