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Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response...

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Main Authors: Schmutz, Maximilian (Author) , Zucknick, Manuela (Author) , Schlenk, Richard Friedrich (Author) , Mertens, Daniel (Author) , Benner, Axel (Author) , Weichenhan, Dieter (Author) , Mücke, Oliver (Author) , Döhner, Konstanze (Author) , Plass, Christoph (Author) , Bullinger, Lars (Author) , Claus, Rainer (Author)
Format: Article (Journal)
Language:English
Published: 26 October 2023
In: Clinical epigenetics
Year: 2023, Volume: 15, Pages: 1-16
ISSN:1868-7083
DOI:10.1186/s13148-023-01580-z
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-023-01580-z
Verlag, kostenfrei, Volltext: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-023-01580-z
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Author Notes:Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger and Rainer Claus
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Summary:Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response exist. Here, we investigated whether unbiased genome-wide assessment of pre-treatment DNA-methylation profiles in AML bone marrow blasts can help to identify patients who will achieve a remission after an azacytidine-containing induction regimen.
Item Description:Gesehen am 05.03.2024
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-023-01580-z

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