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Venlafaxine’s therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis: original investigation

The selective serotonin and norepinephrine reuptake inhibitor venlafaxine is among the most prescribed antidepressant drugs worldwide and, according to guidelines, its dose titration should be guided by drug-level monitoring of its active moiety (AM) which consists of venlafaxine (VEN) plus active m...

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Main Authors: Lense, Xenija M. (Author) , Hiemke, Christoph (Author) , Funk, Cleo (Author) , Havemann-Reinecke, Ursula (Author) , Hefner, Gudrun (Author) , Menke, A. (Author) , Mößner, Rainald (Author) , Riemer, Thomas Günther (Author) , Scherf-Clavel, Maike (Author) , Schoretsanitēs, Geōrgios (Author) , Gründer, Gerhard (Author) , Hart, Xenia Marlene (Author)
Format: Article (Journal)
Language:English
Published: February 2024
In: Psychopharmacology
Year: 2024, Volume: 241, Issue: 2, Pages: 275-289
ISSN:1432-2072
DOI:10.1007/s00213-023-06484-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00213-023-06484-7
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00213-023-06484-7
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Author Notes:X.M. Lense, C. Hiemke, C.S.M. Funk, U. Havemann-Reinecke, G. Hefner, A. Menke, R. Mössner, T.G. Riemer, M. Scherf-Clavel, G. Schoretsanitis, G. Gründer, X.M. Hart
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Summary:The selective serotonin and norepinephrine reuptake inhibitor venlafaxine is among the most prescribed antidepressant drugs worldwide and, according to guidelines, its dose titration should be guided by drug-level monitoring of its active moiety (AM) which consists of venlafaxine (VEN) plus active metabolite O-desmethylvenlafaxine (ODV). This indication of therapeutic drug monitoring (TDM), however, assumes a clear concentration/effect relationship for a drug, which for VEN has not been systematically explored yet.
Item Description:Online veröffentlicht: 19. Oktober 2023
Gesehen am 06.03.2024
Physical Description:Online Resource
ISSN:1432-2072
DOI:10.1007/s00213-023-06484-7

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