Cover Image

Multi-parametric non-contrast cardiac magnetic resonance for the differentiation between cardiac amyloidosis and hypertrophic cardiomyopathy

Aim To evaluate the ability of fast strain-encoded (SENC) cardiac magnetic resonance (CMR) derived myocardial strain and native T1 mapping to discriminate between hypertrophic cardiomyopathy (HCM) and cardiac amyloidosis.Methods Ninety nine patients (57 with hypertrophic cardiomyopathy and 42 with c...

Full description

Saved in:
Bibliographic Details
Main Authors: Steen, Henning (Author) , Montenbruck, Moritz (Author) , Kallifatidis, Alexandros (Author) , André, Florian (Author) , Frey, Norbert (Author) , Kelle, Sebastian (Author) , Korosoglou, Grigorios (Author)
Format: Article (Journal)
Language:English
Published: 14 December 2023
In: Clinical research in cardiology
Year: 2023, Volume: 113, Pages: 469-480
ISSN:1861-0692
DOI:10.1007/s00392-023-02348-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00392-023-02348-4
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00392-023-02348-4
Get full text
Author Notes:Henning Steen, Moritz Montenbruck, Alexandros Kallifatidis, Florian Andre, Norbert Frey, Sebastian Kelle & Grigorios Korosoglou
Description
Summary:Aim To evaluate the ability of fast strain-encoded (SENC) cardiac magnetic resonance (CMR) derived myocardial strain and native T1 mapping to discriminate between hypertrophic cardiomyopathy (HCM) and cardiac amyloidosis.Methods Ninety nine patients (57 with hypertrophic cardiomyopathy and 42 with cardiac amyloidosis) were systematically analysed. LV-ejection fraction, LV-mass index, septal wall thickness and native T1 mapping values were assessed. In addition, global circumferential and longitudinal strain and segmental circumferential and longitudinal strain in basal, mid-ventricular, and apical segments were calculated. A ratio was built by dividing native T1 values by basal segmental strain (T1-to-basal segmental strain ratio).Results Myocardial strain was equally distributed in apical and basal segments in HCM patients, whereas an apical sparing with less impaired apical strain was noticed in cardiac amyloidosis (apical-to-basal-ratio of 1.01 +/- 0.23 versus 1.20 +/- 0.28, p < 0.001). T1 values were significantly higher in amyloidosis compared to HCM patients (1170.7 +/- 66.4 ms versus 1078.3 +/- 57.4ms, p < 0.001). The T1-to-basal segmental strain ratio exhibited high accuracy for the differentiation between the two clinical entities (Sensitivity = 85%, Specificity = 77%, AUC = 0.90, 95% CI = 0.81-0.95, p < 0.001). Multivariable analysis showed that age and the T1-to-basal-strain-ratio were the most robust factors for the differentiation between HCM and cardiac amyloidosis.Conclusion The T1-to-basal-segmental strain ratio, combining information from segmental circumferential and longitudinal strain and native T1 mapping aids the differentiation between HCM and cardiac amyloidosis with high accuracy and within a fast CMR protocol, obviating the need for contrast agent administration.
Item Description:Gesehen am 07.03.2024
Online veröffentlicht: 14. Dezember 2023
Physical Description:Online Resource
ISSN:1861-0692
DOI:10.1007/s00392-023-02348-4

Similar Items