Increased aldosterone-18-glucuronide/tetrahydro-aldosterone ratios in pregnancy
In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone meta...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1995
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| In: |
Endocrine research
Year: 1995, Volume: 21, Issue: 1-2, Pages: 197-202 |
| ISSN: | 1532-4206 |
| DOI: | 10.3109/07435809509030435 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/07435809509030435
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| Author Notes: | J. Wacker, P. Piel, S. Lewicka, D. Haack, P. Vecsei, G. Bastert |
| Summary: | In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone metabolites was found. The Q-ratio (aldosterone-18-glucuronide / tetrahydro-aldosterone + aldosterone-18-glucuronide) was also increased compared to healthy nonpregnant women. The elevated Q-ratios point out to increased formation of aldosterone-18-glucuronide. This predominantly renal metabolite may reflect greater availability of aldosterone molecules for interaction with mineralocorticoid receptor in the kidney. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 7. Juli 2009 Gesehen am 07.03.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1532-4206 |
| DOI: | 10.3109/07435809509030435 |