Buchumschlag

Increased aldosterone-18-glucuronide/tetrahydro-aldosterone ratios in pregnancy

In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone meta...

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Bibliographische Detailangaben
Hauptverfasser: Wacker, Jürgen (Verfasst von) , Piel, P. (Verfasst von) , Lewicka, Sabina (Verfasst von) , Haack, Doris (Verfasst von) , Vecsei, Pál (Verfasst von) , Bastert, Gunther (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1995
In: Endocrine research
Year: 1995, Jahrgang: 21, Heft: 1-2, Pages: 197-202
ISSN:1532-4206
DOI:10.3109/07435809509030435
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/07435809509030435
Volltext
Verfasserangaben:J. Wacker, P. Piel, S. Lewicka, D. Haack, P. Vecsei, G. Bastert
Beschreibung
Zusammenfassung:In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone metabolites was found. The Q-ratio (aldosterone-18-glucuronide / tetrahydro-aldosterone + aldosterone-18-glucuronide) was also increased compared to healthy nonpregnant women. The elevated Q-ratios point out to increased formation of aldosterone-18-glucuronide. This predominantly renal metabolite may reflect greater availability of aldosterone molecules for interaction with mineralocorticoid receptor in the kidney.
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe 7. Juli 2009
Gesehen am 07.03.2024
Beschreibung:Online Resource
ISSN:1532-4206
DOI:10.3109/07435809509030435

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