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Circulating oxysterols and prognosis among women with a breast cancer diagnosis: results from the MARIE patient cohort

Breast cancer is the most commonly diagnosed cancer in women worldwide, and underlying mechanistic pathways associated with breast cancer-specific and non-breast cancer-related deaths are of importance. Emerging evidence suggests a role of oxysterols, derivates of cholesterol, in multiple chronic di...

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Main Authors: Decker, Nina Sophia (Author) , Johnson, Theron S. (Author) , Vey, Johannes (Author) , Le Cornet, Charlotte (Author) , Behrens, Sabine (Author) , Obi, Nadia (Author) , Kaaks, Rudolf (Author) , Chang-Claude, Jenny (Author) , Turzanski Fortner, Renée (Author)
Format: Article (Journal)
Language:English
Published: 14 November 2023
In: BMC medicine
Year: 2023, Volume: 21, Issue: 1, Pages: 1-12
ISSN:1741-7015
DOI:10.1186/s12916-023-03152-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12916-023-03152-7
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Author Notes:Nina Sophia Decker, Theron Johnson, Johannes A. Vey, Charlotte Le Cornet, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude and Renée Turzanski Fortner
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Summary:Breast cancer is the most commonly diagnosed cancer in women worldwide, and underlying mechanistic pathways associated with breast cancer-specific and non-breast cancer-related deaths are of importance. Emerging evidence suggests a role of oxysterols, derivates of cholesterol, in multiple chronic diseases including breast cancer and coronary artery diseases. However, associations between oxysterols and survival have been minimally studied in women diagnosed with breast cancer. In this large breast cancer patient cohort, we evaluated associations between a panel of circulating oxysterols and mortality and recurrence outcomes.
Item Description:Gesehen am 11.03.2024
Physical Description:Online Resource
ISSN:1741-7015
DOI:10.1186/s12916-023-03152-7

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