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Initial results with (18F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-68-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-18-labeled FAP ligands might provide q...

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Main Authors: Mori, Yuriko (Author) , Kramer, Vasko (Author) , Novruzov, Emil (Author) , Mamlins, Eduards (Author) , Röhrich, Manuel (Author) , Fernandez, Rene (Author) , Amaral, Horacio (Author) , Soza-Ried, Cristian A. (Author) , Monje, Barbara (Author) , Sabbagh, Eduardo (Author) , Florenzano, Matias (Author) , Giesel, Frederik L. (Author) , Undurraga, Alvaro (Author)
Format: Article (Journal)
Language:English
Published: 20 December 2023
In: European journal of nuclear medicine and molecular imaging
Year: 2024, Volume: 51, Issue: 6, Pages: 1605-1611
ISSN:1619-7089
DOI:10.1007/s00259-023-06564-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00259-023-06564-y
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00259-023-06564-y
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Author Notes:Yuriko Mori, Vasko Kramer, Emil Novruzov, Eduards Mamlins, Manuel Roehrich, Rene Fernandez, Horacio Amaral, Cristian Soza-Ried, Barbara Monje, Eduardo Sabbagh, Matias Florenzano, Frederik L. Giesel & Alvaro Undurraga
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Summary:Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-68-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-18-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [F-18]FAPI-74 prospectively in a small patient cohort.Methods: Eight patients underwent both [F-18]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters.Results: We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung.Conclusion: The initial results confirm our assumption that [F-18]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF.
Item Description:Im Titel steht 18F in eckiger Klammer, die Zahl 18 ist dabei hochgestellt
Gesehen am 11.03.2024
Physical Description:Online Resource
ISSN:1619-7089
DOI:10.1007/s00259-023-06564-y

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