Editorial: neurotrauma and repair: from peripheral to central nerve injury
Neurotrauma, encompassing traumatic brain injury (TBI), peripheral nerve injury (PNI), and spinal cord injury (SCI), continues to be a major global public health concern. The complex pathophysiological mechanisms and lifelong neurological deficits associated with neurotrauma emphasize the urgent nee...
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
01 December 2023
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| In: |
Frontiers in molecular neuroscience
Year: 2023, Volume: 16, Pages: 1-2 |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2023.1338869 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fnmol.2023.1338869 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fnmol.2023.1338869 
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| Author Notes: | Alexander Younsi |
| Summary: | Neurotrauma, encompassing traumatic brain injury (TBI), peripheral nerve injury (PNI), and spinal cord injury (SCI), continues to be a major global public health concern. The complex pathophysiological mechanisms and lifelong neurological deficits associated with neurotrauma emphasize the urgent need for effective clinical interventions. The research topic "Neurotrauma and Repair: from Peripheral to Central Nerve Injury" brought together a diverse group of 58 authors, fostering interdisciplinary collaboration, and offering new insights into the multifaceted landscape of neurotrauma research.This collaborative effort yielded a body of work that has garnered significant attention within the scientific community, underscoring the importance of the research contributions and the demand for advances in neurotrauma understanding and treatment."Effects of a Neurokinin-1 Receptor Antagonist in the Acute Phase after Thoracic Spinal Cord Injury in a Rat Model" delves into the potential therapeutic effects of neurokinin-1 receptor antagonists on neuroinflammation and edema following SCI. While the study suggests limited impact on reducing edema, it demonstrates a notable reduction in T-lymphocyte invasion and apoptotic cell numbers with the treatment. Additionally, it hints at a trend towards reduced fibrinogen leakage, endothelial and microglial activation, chondroitin sulfate glycosaminoglycan deposition, and astrogliosis. Although general locomotion recovery remained modest, the C... |
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| Item Description: | Gesehen am 12.03.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2023.1338869 |