Progenitor-like cell type of an MLL-EDC4 fusion in acute myeloid leukemia: to the editor
TO THE EDITOR:Translocations involving the mixed lineage leukemia (MLL/KMT2A) gene generally confer poor prognosis in acute myeloid leukemia (AML) and display a large intertumor and intratumor heterogeneity.1 By conducting a single-cell RNA sequencing (scRNA-seq) analysis, the different developmenta...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
November 20, 2023
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| In: |
Blood advances
Year: 2023, Volume: 7, Issue: 22, Pages: 7079-7083 |
| ISSN: | 2473-9537 |
| DOI: | 10.1182/bloodadvances.2022009096 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1182/bloodadvances.2022009096 Verlag, kostenfrei, Volltext: https://ashpublications.org/bloodadvances/article/7/22/7079/498306/Progenitor-like-cell-type-of-an-MLL-EDC4-fusion-in 
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| Author Notes: | Linda C. Schuster, Afzal P. Syed, Stephan M. Tirier, Simon Steiger, Isabelle Seufert, Heiko Becker, Jesus Duque-Afonso, Tobias Ma, Seishi Ogawa, Jan-Philipp Mallm, Michael Lübbert, and Karsten Rippe |
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| 520 | |a TO THE EDITOR:Translocations involving the mixed lineage leukemia (MLL/KMT2A) gene generally confer poor prognosis in acute myeloid leukemia (AML) and display a large intertumor and intratumor heterogeneity.1 By conducting a single-cell RNA sequencing (scRNA-seq) analysis, the different developmental stages along the hematopoietic stem cell (HSC) to myeloid trajectory can be resolved, which is relevant for self-renewal, interactions of leukemic cells with nonmalignant cells in the microenvironment, and therapy resistance.2-5 However, information on MLL-rearranged (MLL-r) cases of AML is scarce as previous scRNA-seq studies of AML by van Galen et al2 and Shlush et al3 include only 1 patient with MLL-r each. In our previous work, we have described a novel MLL fusion with the enhancer of messenger RNA decapping 4 gene (MLL-EDC4),6 for which recently another case has been reported.7 | ||
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