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Progenitor-like cell type of an MLL-EDC4 fusion in acute myeloid leukemia: to the editor

TO THE EDITOR:Translocations involving the mixed lineage leukemia (MLL/KMT2A) gene generally confer poor prognosis in acute myeloid leukemia (AML) and display a large intertumor and intratumor heterogeneity.1 By conducting a single-cell RNA sequencing (scRNA-seq) analysis, the different developmenta...

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Main Authors: Schuster, Linda (Author) , Syed, Afzal Pasha (Author) , Tirier, Stephan Marius (Author) , Steiger, Simon (Author) , Seufert, Isabelle (Author) , Becker, Heiko (Author) , Duque Afonso, Jesús (Author) , Ma, Tobias (Author) , Ogawa, Seishi (Author) , Mallm, Jan-Philipp (Author) , Lübbert, Michael (Author) , Rippe, Karsten (Author)
Format: Article (Journal) Editorial
Language:English
Published: November 20, 2023
In: Blood advances
Year: 2023, Volume: 7, Issue: 22, Pages: 7079-7083
ISSN:2473-9537
DOI:10.1182/bloodadvances.2022009096
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1182/bloodadvances.2022009096
Verlag, kostenfrei, Volltext: https://ashpublications.org/bloodadvances/article/7/22/7079/498306/Progenitor-like-cell-type-of-an-MLL-EDC4-fusion-in
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Author Notes:Linda C. Schuster, Afzal P. Syed, Stephan M. Tirier, Simon Steiger, Isabelle Seufert, Heiko Becker, Jesus Duque-Afonso, Tobias Ma, Seishi Ogawa, Jan-Philipp Mallm, Michael Lübbert, and Karsten Rippe
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Summary:TO THE EDITOR:Translocations involving the mixed lineage leukemia (MLL/KMT2A) gene generally confer poor prognosis in acute myeloid leukemia (AML) and display a large intertumor and intratumor heterogeneity.1 By conducting a single-cell RNA sequencing (scRNA-seq) analysis, the different developmental stages along the hematopoietic stem cell (HSC) to myeloid trajectory can be resolved, which is relevant for self-renewal, interactions of leukemic cells with nonmalignant cells in the microenvironment, and therapy resistance.2-5 However, information on MLL-rearranged (MLL-r) cases of AML is scarce as previous scRNA-seq studies of AML by van Galen et al2 and Shlush et al3 include only 1 patient with MLL-r each. In our previous work, we have described a novel MLL fusion with the enhancer of messenger RNA decapping 4 gene (MLL-EDC4),6 for which recently another case has been reported.7
Item Description:Gesehen am 12.03.2024
Physical Description:Online Resource
ISSN:2473-9537
DOI:10.1182/bloodadvances.2022009096

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