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Osteopontin but not osteonectin favors the metastatic growth of pancreatic cancer cell lines

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer- related death in Western countries and among the malignancies with the worst prognosis. Osteonectin and osteopontin, two proteins of the extracellular matrix, have been found to be up-regulated in PDAC. In the present stu...

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Main Authors: Zhivkova-Galunska, Maria (Author) , Adwan, Hassan (Author) , Eyol, Ergül (Author) , Kleeff, Jörg H. (Author) , Kolb, Armin (Author) , Bergmann, Frank (Author) , Berger, Martin R. (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Cancer biology & therapy
Year: 2010, Volume: 10, Issue: 1, Pages: 54-64
ISSN:1555-8576
DOI:10.4161/cbt.10.1.12161
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4161/cbt.10.1.12161
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Author Notes:Maria Zhivkova-Galunska, Hassan Adwan, Ergül Eyol, Jörg Kleeff, Armin Kolb, Frank Bergmann, Martin R. Berger
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Summary:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer- related death in Western countries and among the malignancies with the worst prognosis. Osteonectin and osteopontin, two proteins of the extracellular matrix, have been found to be up-regulated in PDAC. In the present study the expression of osteopontin mRNA as determined in a panel of 14 hu­man pancreatic cancer cell lines was significantly related to the growth these cell lines in the liver of nude rats (p=0.001) whereas osteonectin showed a trend of being negatively related to pancreatic cancer cell growth in vivo (p=0.10). In an in vitro co-culture model of human Suit2-007 and rat AsML PDAC cells with rat hepatocytes, a clearly increased expression of OPN mRNA was found in the tumor cells. In addition both, down-regulation of osteopontin with specific antisense oligonucleotides and treatment with exogenous rh-osteonectin were associated with reduced cell proliferation. In accordance with the latter finding down-regula­tion of osteonectin was coupled with increased proliferation. This evidence supports a protu­morigenic role of osteopontin and points to an anti-tumorigenic role of osteonectin in PDAC.
Item Description:Gesehen am 12.03.2024
Physical Description:Online Resource
ISSN:1555-8576
DOI:10.4161/cbt.10.1.12161

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