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Loss of miR-192-5p initiates a hyperglycolysis and stemness positive feedback in hepatocellular carcinoma

Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar metabolic properties, which however remained largely unknown in hepatocellular carcinoma (HCC). Genetic silencing of liver-abundant miR-192-5p was a key feature for multiple groups of CSC-positive HCCs. We thus aimed to inves...

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Main Authors: Gu, Yuanzhuo (Author) , Ji, Fubo (Author) , Liu, Niya (Author) , Zhao, Yongzhi (Author) , Wei, Xiyang (Author) , Hu, Shiyuan (Author) , Jia, Wei (Author) , Wang, Xin Wei (Author) , Budhu, Anuradha (Author) , Ji, Juling (Author) , Zhao, Bin (Author) , Rössler, Stephanie (Author) , Zheng, Xin (Author) , Ji, Junfang (Author)
Format: Article (Journal)
Language:English
Published: 30 November 2020
In: Journal of experimental & clinical cancer research
Year: 2020, Volume: 39, Pages: 1-17
ISSN:1756-9966
DOI:10.1186/s13046-020-01785-7
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13046-020-01785-7
Verlag, kostenfrei, Volltext: https://jeccr.biomedcentral.com/articles/10.1186/s13046-020-01785-7
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Author Notes:Yuanzhuo Gu, Fubo Ji, Niya Liu, Yongzhi Zhao, Xiyang Wei, Shiyuan Hu, Wei Jia, Xin Wei Wang, Anuradha Budhu, Juling Ji, Bin Zhao, Stephanie Roessler, Xin Zheng and Junfang Ji
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Summary:Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar metabolic properties, which however remained largely unknown in hepatocellular carcinoma (HCC). Genetic silencing of liver-abundant miR-192-5p was a key feature for multiple groups of CSC-positive HCCs. We thus aimed to investigate essential metabolic features of hepatic CSCs via using HCCs with miR-192-5p silencing as a model.
Item Description:Gesehen am 13.03.2024
Physical Description:Online Resource
ISSN:1756-9966
DOI:10.1186/s13046-020-01785-7

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