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Living-donor liver transplantation for a large hepatocellular carcinoma in a genetically identical twin sister

<p>Hepatocellular carcinoma (HCC) is, to date, the most common malignant tumor of the liver and is commonly staged with the Milan criteria. While deceased-donor liver transplantations (DDLT) are reserved for patients within the Milan criteria, living-donor liver transplantation (LDLT) might be...

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Main Authors: Koek, Ger (Author) , Schmitz, Sophia (Author) , Bednarsch, Jan (Author) , Heise, Daniel (Author) , Longerich, Thomas (Author) , Bakers, Frank (Author) , Trautwein, Christian (Author) , Lüdde, Tom (Author) , Ulmer, Tom Florian (Author) , Neumann, Ulf Peter (Author)
Format: Article (Journal)
Language:English
Published: 09. Januar 2024
In: Zeitschrift für Gastroenterologie
Year: 2024, Volume: 62, Issue: 1, Pages: 56-61
ISSN:1439-7803
DOI:10.1055/a-2214-1712
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1055/a-2214-1712
Verlag, kostenfrei, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-2214-1712
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Author Notes:Ger Koek, Sophia M. Schmitz, Jan Bednarsch, Daniel Heise, Thomas Longerich, Frank Bakers, Christian Trautwein, Tom Luedde, Tom Florian Ulmer, Ulf Peter Neumann
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Summary:<p>Hepatocellular carcinoma (HCC) is, to date, the most common malignant tumor of the liver and is commonly staged with the Milan criteria. While deceased-donor liver transplantations (DDLT) are reserved for patients within the Milan criteria, living-donor liver transplantation (LDLT) might be a curative option for patients outside the Milan criteria. We here report a case of a 32-year-old woman who developed a giant, unresectable HCC out of a hepatocellular adenoma (HCA) after a pregnancy. The genetically identical twin sister donated her left hemi-liver after ethical approval and preoperative screening. No long-term immunosuppressive therapy was necessary, and after more than eight years, both are in perfect health and the recipient gave birth to a second child. This case shows that in certain situations large HCCs outside the standard criteria can be cured by LT. Careful evaluation of both donor and recipient should be performed for indications like this to assure optimal clinical outcome.</p>
Item Description:Gesehen am 15.03.2024
Physical Description:Online Resource
ISSN:1439-7803
DOI:10.1055/a-2214-1712

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